{"id":"W2133356144","doi":"10.1084/jem.20020307","title":"CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly","year":2002,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cell biology; Protein kinase B; PI3K/AKT/mTOR pathway; Biology; CD28; Signal transduction; Phosphatidylinositol; Jurkat cells; Apoptosis; Programmed cell death; Kinase; AKT1; T cell; Immunology; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005289054,0.0001413387,0.0002219072,0.00005958958,0.00009950047,0.000006787284,0.0001663531,0.00008484435,0.0001773668],"category_scores_gemma":[0.00007858181,0.00009259367,0.00006997341,0.00008014487,0.00005345661,0.00001154266,0.00005094684,0.0001251429,6.062732e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003897569,"about_ca_system_score_gemma":0.00001276035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003607312,"about_ca_topic_score_gemma":4.483305e-7,"domain_scores_codex":[0.998742,0.0001187465,0.0005051193,0.0001190441,0.0003601109,0.0001549973],"domain_scores_gemma":[0.9990433,0.00003085369,0.0005924366,0.0001516934,0.000109047,0.00007269692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036571,0.0001562453,0.00003004794,0.00001057859,0.00006999447,0.000001008543,0.0004935565,0.00009524146,0.9974934,0.000008409399,0.000402025,0.001135785],"study_design_scores_gemma":[0.00123604,0.001145785,0.00004099234,0.0002178596,0.00004693697,0.0000299755,0.001318624,0.0009145921,0.9946603,0.00001047489,0.0002856977,0.00009274459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932985,0.002789906,0.003080377,0.000299539,0.0001056769,0.0002430913,0.00000207202,0.000003771753,0.0001770274],"genre_scores_gemma":[0.9987714,0.0001144126,0.000444006,0.00007564214,0.0003263321,0.00000445013,0.00002447508,0.00001743979,0.0002218952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005472808,"threshold_uncertainty_score":0.377586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785978216769232,"score_gpt":0.2704174515697827,"score_spread":0.2425576694020904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}