{"id":"W2133386306","doi":"10.1158/0008-5472.can-07-5472","title":"Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"RAD51; Homologous recombination; Radioresistance; DNA repair; Biology; Molecular biology; Cell cycle; DNA damage; Radiosensitivity; Cancer research; Cell biology; Chemistry; Cell; Cell culture; DNA; Radiation therapy; Biochemistry; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483093,0.0002748886,0.0004364218,0.0001305487,0.0000835169,0.0003074296,0.0001913506,0.0002846943,0.001213916],"category_scores_gemma":[0.0001418777,0.000138557,0.0002232418,0.0001159448,0.0001844097,0.0002619624,0.0002280805,0.0004455381,0.0002019821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003504662,"about_ca_system_score_gemma":0.0002404791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006110517,"about_ca_topic_score_gemma":0.0009756948,"domain_scores_codex":[0.9998484,0.00002096751,0.00001675171,0.00003744642,0.00003624264,0.00004012157],"domain_scores_gemma":[0.9997581,0.00003319155,0.00009285714,0.00002418496,0.00003120777,0.00006045718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000588636,0.00001735679,0.0001354792,0.0000294301,0.00000446583,0.00001175302,0.000005042682,0.00003172033,0.9989231,0.00003204365,0.00003749621,0.0007131328],"study_design_scores_gemma":[0.00001758218,0.0007733954,0.01221543,0.00001101738,0.00002521583,0.0002292382,0.00002341264,0.0006830673,0.9821088,0.0000424655,0.003865918,0.000004433146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880698,0.005625128,0.004113229,0.0002392571,0.00007331878,0.0000406778,0.0003835605,0.0001573432,0.001297829],"genre_scores_gemma":[0.9910595,0.002659381,0.002894651,0.0001397904,0.00003796661,0.00005362909,0.0006789397,0.00005056581,0.002425657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213916,"threshold_uncertainty_score":0.004060924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081393139601044,"score_gpt":0.3200716522869141,"score_spread":0.2892577208909037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}