{"id":"W2133387500","doi":"10.1371/journal.pone.0074362","title":"Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Boehringer Ingelheim Stiftung; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Max-Planck-Institut für Kognitions- und Neurowissenschaften; University of Alberta","keywords":"Orbitofrontal cortex; Disinhibition; Prefrontal cortex; Genome-wide association study; Amygdala; Allele; Binge eating; Disordered eating; Brain size; Obesity; Medicine; Biology; Genetics; Single-nucleotide polymorphism; Neuroscience; Eating disorders; Internal medicine; Clinical psychology; Cognition; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001523962,0.0004243203,0.0003590551,0.0004781712,0.0002248638,0.000269082,0.0001940582,0.00032228,0.003897271],"category_scores_gemma":[0.0004737179,0.0001199469,0.0003399245,0.0004464145,0.0002872528,0.00008108284,0.0002693836,0.0002473043,0.0001963735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001636063,"about_ca_system_score_gemma":0.0001616552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002607992,"about_ca_topic_score_gemma":0.002857325,"domain_scores_codex":[0.9997696,0.00004423311,0.00001592791,0.00009351611,0.00005302458,0.00002356909],"domain_scores_gemma":[0.9997353,0.00006362695,0.0001270223,0.00003462618,0.00001405253,0.00002538723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001451577,0.0001298194,0.6775299,0.000210915,0.001526875,0.002827347,0.0003467482,0.0002403163,0.279414,0.0006731961,0.000635193,0.03501415],"study_design_scores_gemma":[0.00001368676,0.00008918433,0.9958603,0.000007800424,0.0001034946,0.001004518,0.00003094956,0.00008821392,0.002060778,0.0001656982,0.0005701261,0.000005283631],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959891,0.001685019,0.0004467985,0.0001146061,0.00001379742,0.000009864721,0.00070123,0.00003071162,0.001008878],"genre_scores_gemma":[0.9978781,0.0005026585,0.0004999699,0.00006819611,0.00002145106,0.00001108023,0.0004296625,0.00001551636,0.0005734516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003897271,"threshold_uncertainty_score":0.01303768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06849665007047931,"score_gpt":0.2749403979664815,"score_spread":0.2064437478960022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}