{"id":"W2133387500","doi":"10.1371/journal.pone.0074362","title":"Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Boehringer Ingelheim Stiftung; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Max-Planck-Institut für Kognitions- und Neurowissenschaften; University of Alberta","keywords":"Orbitofrontal cortex; Disinhibition; Prefrontal cortex; Genome-wide association study; Amygdala; Allele; Binge eating; Disordered eating; Brain size; Obesity; Medicine; Biology; Genetics; Single-nucleotide polymorphism; Neuroscience; Eating disorders; Internal medicine; Clinical psychology; Cognition; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000504056,0.0001292932,0.0001572238,0.000054042,0.0004111868,0.0003187219,0.0001100002,0.00007114542,0.0005150558],"category_scores_gemma":[0.00003807918,0.0001121395,0.00002857901,0.0001107767,0.00008181392,0.0001705534,0.0000392028,0.00014258,0.00006627011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003677491,"about_ca_system_score_gemma":0.000009851602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001058466,"about_ca_topic_score_gemma":0.000008824371,"domain_scores_codex":[0.9989693,0.00009365111,0.0001682131,0.0002910735,0.0002986979,0.0001790966],"domain_scores_gemma":[0.9994318,0.0001103494,0.00009251662,0.0002548296,0.00002591309,0.000084569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00000584721,0.0002349181,0.05956781,0.00001132965,0.000004708415,0.000002647867,0.0004784321,0.0000443607,0.9381285,0.0001092846,0.00007814007,0.001334002],"study_design_scores_gemma":[0.0002366053,0.0002084135,0.8223274,0.0000302994,0.00001178235,0.00000288289,0.000006105124,0.002354995,0.174151,0.0005357328,0.0000233941,0.0001113469],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989256,0.00001198427,0.00001248334,0.0003358668,0.00001668514,0.0004502339,0.00001579307,0.00005788411,0.0001734734],"genre_scores_gemma":[0.9985911,0.000004101216,0.0008310686,0.0002435263,0.00009060986,0.00001512213,0.000008246559,0.00001789408,0.0001983581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7639775,"threshold_uncertainty_score":0.5639501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06849665007047931,"score_gpt":0.2749403979664815,"score_spread":0.2064437478960022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}