{"id":"W2133419523","doi":"10.1242/jcs.122895","title":"Mature MiR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7, and vimentin in different signal pathways","year":2013,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Lawson Health Research Institute; University of Toronto; Western University; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Vimentin; PTEN; microRNA; Gene silencing; Cell biology; Signal transduction; Carcinogenesis; Small interfering RNA; Cancer research; Transfection; Cancer; Cell culture; PI3K/AKT/mTOR pathway; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771124,0.0003733601,0.0002775521,0.0002382103,0.00009964276,0.0002211301,0.0001500736,0.0001908628,0.0009552731],"category_scores_gemma":[0.0001144146,0.0002264238,0.0004040756,0.0001159147,0.0002121453,0.0002038876,0.0002514118,0.0004190119,0.0002969237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914789,"about_ca_system_score_gemma":0.0003061237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002460036,"about_ca_topic_score_gemma":0.0004743166,"domain_scores_codex":[0.9998081,0.00002882953,0.00001944262,0.00002559822,0.00005984359,0.00005815877],"domain_scores_gemma":[0.9998988,0.00001719726,0.0000338085,0.00001006331,0.00001011819,0.00002992213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287273,0.00002875158,0.0002681887,0.00002826723,0.000005974658,0.00007568809,0.00001540866,0.0000472326,0.998383,0.0001687354,0.00002007135,0.0008299361],"study_design_scores_gemma":[0.00001539306,0.0003830141,0.002005541,0.000002475386,0.00002326294,0.0002151769,0.00002108525,0.0008089447,0.9949361,0.00005791953,0.001528216,0.000002846294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938611,0.0008289401,0.003534978,0.00006485587,0.00002743388,0.00004144119,0.000143666,0.00009853473,0.001399136],"genre_scores_gemma":[0.9940249,0.0005821796,0.003117205,0.00004615261,0.000009278305,0.00005749211,0.0002992988,0.00002576852,0.001837764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009552731,"threshold_uncertainty_score":0.003195763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00704099799502941,"score_gpt":0.2013960681182499,"score_spread":0.1943550701232205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}