{"id":"W2133419523","doi":"10.1242/jcs.122895","title":"Mature MiR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7, and vimentin in different signal pathways","year":2013,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Lawson Health Research Institute; University of Toronto; Western University; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Vimentin; PTEN; microRNA; Gene silencing; Cell biology; Signal transduction; Carcinogenesis; Small interfering RNA; Cancer research; Transfection; Cancer; Cell culture; PI3K/AKT/mTOR pathway; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004409357,0.0001631212,0.000176591,0.00009550559,0.0001021574,0.0001154013,0.0002171475,0.0001130282,0.00004774987],"category_scores_gemma":[0.00003659637,0.0001270637,0.00004901556,0.0001333064,0.0001940863,0.00004005322,0.0001389405,0.0001772707,0.000001259089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003554182,"about_ca_system_score_gemma":0.00008937328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001188357,"about_ca_topic_score_gemma":0.000001689585,"domain_scores_codex":[0.9986873,0.00006010853,0.0003423306,0.0002940662,0.0003170718,0.0002991081],"domain_scores_gemma":[0.9991742,0.00001584324,0.0002889479,0.0001344064,0.0001580503,0.0002285676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001753132,0.0000657206,0.02920263,0.00002137216,0.000004621401,0.000007108059,0.00008389616,0.000005793866,0.9672694,0.000001777567,0.003138931,0.0001811864],"study_design_scores_gemma":[0.0004899522,0.0001226444,0.08893032,0.00003406366,0.0000128612,0.000038509,0.0001130222,0.000907138,0.9075442,0.00006168938,0.001578698,0.00016693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954662,0.003788196,0.0001965804,0.0002069231,0.00006302776,0.000162073,0.000005103378,0.000002144964,0.0001097864],"genre_scores_gemma":[0.9988601,0.00008816234,0.0007348051,0.00008615225,0.0001019691,0.000003727763,0.000006846246,0.00001047307,0.0001077466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05972769,"threshold_uncertainty_score":0.5181508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00704099799502941,"score_gpt":0.2013960681182499,"score_spread":0.1943550701232205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}