{"id":"W2133428384","doi":"10.1016/s0960-894x(01)00778-8","title":"New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D2 Template","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Derivative (finance); Stereochemistry; Dopaminergic; Resolution (logic); Bicyclic molecule; Combinatorial chemistry; Chemical synthesis; Dopamine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827015,0.0004084138,0.0002622813,0.0003744565,0.0001432091,0.0002141614,0.0006444019,0.0005123719,0.003212941],"category_scores_gemma":[0.00009921809,0.0001919802,0.0003478573,0.0001605565,0.0002458416,0.0003940082,0.0002077303,0.0004925954,0.001170328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003018749,"about_ca_system_score_gemma":0.0002094908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004647643,"about_ca_topic_score_gemma":0.0008005137,"domain_scores_codex":[0.999949,0.000006387839,0.000003013623,0.00001046924,0.00001247362,0.00001871388],"domain_scores_gemma":[0.9999688,0.000007464841,0.000006816446,0.000005394407,0.000003246198,0.000008372976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001118691,0.0009085435,0.000482788,0.0007104332,0.00007766194,0.0008301066,0.0001954411,0.002734166,0.7727733,0.01257858,0.009365112,0.1982252],"study_design_scores_gemma":[0.0004754599,0.006239301,0.003961586,0.00006255703,0.00010398,0.002240172,0.00004721539,0.002160877,0.827773,0.002109368,0.1547505,0.0000760065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6997657,0.1430649,0.05419045,0.002064575,0.00199298,0.001074422,0.002312771,0.001234248,0.09430005],"genre_scores_gemma":[0.8646718,0.05863619,0.01557251,0.001679805,0.0005997072,0.00048152,0.001803013,0.0001100447,0.05644541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003212941,"threshold_uncertainty_score":0.01074833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05018907009406931,"score_gpt":0.2330683860108327,"score_spread":0.1828793159167634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}