{"id":"W2133479741","doi":"10.2217/pgs.14.83","title":"Pharmacogenetics of Antidepressant Treatment in Obsessive–Compulsive Disorder: An Update and Implications for Clinicians","year":2014,"lang":"en","type":"review","venue":"Pharmacogenomics","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Centre for Addiction and Mental Health; Sunnybrook Health Science Centre","funders":"","keywords":"Antidepressant; Pharmacogenetics; Tolerability; Psychiatry; Serotonergic; Medicine; Genetic testing; Endophenotype; Fluvoxamine; Psychology; Bioinformatics; Pharmacology; Fluoxetine; Cognition; Internal medicine; Genetics; Anxiety; Gene; Serotonin; Biology; Adverse effect; Genotype; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003317713,0.0009897986,0.003063462,0.0005742837,0.0001520408,0.00004622527,0.0008473036,0.000377517,0.0001155154],"category_scores_gemma":[0.00003509568,0.0009500082,0.0007225373,0.0004112343,0.0003108285,0.00009871785,0.0001685021,0.0003859096,0.00004064586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202587,"about_ca_system_score_gemma":0.0003106559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001750207,"about_ca_topic_score_gemma":0.0001308526,"domain_scores_codex":[0.995166,0.0006343157,0.001865325,0.001391284,0.0001165463,0.0008265097],"domain_scores_gemma":[0.9961011,0.0009133718,0.001609649,0.0009511343,0.0001365045,0.0002882114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009349253,0.00117422,0.003478809,0.002228881,0.0009890773,0.000007638904,0.0003437892,0.00007652538,0.00001425059,0.001746067,0.0001188472,0.9897284],"study_design_scores_gemma":[0.004815017,0.0004943037,0.001413152,0.0005679352,0.003634722,0.0000453714,0.0001584963,0.0002685401,0.00001380355,0.0008246635,0.9866871,0.001076949],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005303551,0.98357,0.001486077,0.0001191576,0.00092454,0.004771891,0.003526408,0.00006221487,0.0002361101],"genre_scores_gemma":[0.002707814,0.9925646,0.001206155,0.0001473798,0.0003528904,0.001451794,0.00125105,0.0002735695,0.00004474282],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9886515,"threshold_uncertainty_score":0.9992951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06554360388748047,"score_gpt":0.438594262766883,"score_spread":0.3730506588794025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}