{"id":"W2133500432","doi":"10.4049/jimmunol.169.2.758","title":"The B Cell Antigen Receptor Regulates the Transcriptional Activator β-Catenin Via Protein Kinase C-Mediated Inhibition of Glycogen Synthase Kinase-3","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"GSK-3; Protein kinase B; GSK3B; Wnt signaling pathway; Glycogen synthase; Phosphorylation; Beta-catenin; Cell biology; Molecular biology; PI3K/AKT/mTOR pathway; Cyclin D1; Biology; Chemistry; Cancer research; Signal transduction; Cell cycle; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695155,0.000320775,0.0001561063,0.0003420051,0.0001508207,0.0003398076,0.0001532896,0.0001753266,0.002106162],"category_scores_gemma":[0.0001354434,0.0001306184,0.0003987067,0.000215263,0.0002202295,0.0001590628,0.0002532184,0.0005000301,0.0006091151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004889111,"about_ca_system_score_gemma":0.0002962335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007390414,"about_ca_topic_score_gemma":0.001147664,"domain_scores_codex":[0.9998682,0.00002114012,0.0000100982,0.00002036056,0.0000418695,0.00003839802],"domain_scores_gemma":[0.9999295,0.000008194545,0.00002831032,0.000005942501,0.000009941041,0.00001801911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001285128,0.0000458195,0.0003682645,0.0001070441,0.00001394069,0.00009117094,0.00001385757,0.0001199772,0.9940394,0.0005842045,0.0002910825,0.004196638],"study_design_scores_gemma":[0.0001648799,0.0005829777,0.02109211,0.00004519511,0.00005679467,0.000692232,0.00005649404,0.003714069,0.9543519,0.0007056952,0.01852178,0.00001594538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471093,0.02376436,0.008679305,0.0007642022,0.0001937304,0.0001567622,0.000714785,0.0005379575,0.01807952],"genre_scores_gemma":[0.9883686,0.004108436,0.001823031,0.0001600112,0.00002109188,0.00008661031,0.0003453553,0.00001902631,0.005067937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002106162,"threshold_uncertainty_score":0.007045805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009356028062950928,"score_gpt":0.1989731225774425,"score_spread":0.1896170945144916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}