{"id":"W2133519987","doi":"10.1128/aac.49.9.3646-3651.2005","title":"Inactivation of Sterol Δ <sup>5,6</sup> -Desaturase Attenuates Virulence in <i>Candida albicans</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Virulence; Ergosterol; Mutant; Biology; Candida albicans; Microbiology; Sterol; Wild type; Mutation; Corpus albicans; Gene; Genetics; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083656,0.0004243815,0.000236887,0.0001528851,0.0001132878,0.0003796494,0.0003124266,0.0002955235,0.00075981],"category_scores_gemma":[0.0001359758,0.0001346228,0.000227136,0.0001198939,0.0002271893,0.0001137485,0.0001537351,0.0004440744,0.0002952762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795308,"about_ca_system_score_gemma":0.0002741829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001467181,"about_ca_topic_score_gemma":0.002175263,"domain_scores_codex":[0.9998478,0.00002496577,0.00002349162,0.00002144881,0.00003665327,0.00004563983],"domain_scores_gemma":[0.9998542,0.00001996339,0.0000501815,0.00001630351,0.00001492354,0.00004440741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002039563,0.00004017187,0.0002722867,0.00001743622,0.000005574751,0.00006105964,0.000006082214,0.00004836258,0.9984749,0.00004402073,0.0000327152,0.0007933035],"study_design_scores_gemma":[0.00003724619,0.0005875084,0.009528089,0.00001096497,0.0000302237,0.0005383841,0.00004937073,0.001090606,0.9868485,0.00003844934,0.00123356,0.000007021162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975637,0.0005363388,0.000648064,0.00009441355,0.00001589683,0.00001571358,0.0002880386,0.00004132923,0.0007964181],"genre_scores_gemma":[0.9976951,0.0003209074,0.0007777039,0.00006349983,0.000005896718,0.000013251,0.0003234554,0.00001835647,0.0007816612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467181,"threshold_uncertainty_score":0.00291723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074817854719228,"score_gpt":0.261706458736618,"score_spread":0.2509582801894257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}