{"id":"W2133531126","doi":"10.1016/j.cell.2006.06.040","title":"Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast","year":2006,"lang":"en","type":"article","venue":"Cell","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":529,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Mode of action; Natural product; Yeast; Computational biology; Drug discovery; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003964754,0.00005583395,0.0001249548,0.00003240582,0.00001128685,0.00000220659,0.00004123934,0.00002662527,0.000008089793],"category_scores_gemma":[0.00001141619,0.00003600695,0.00003176516,0.000126033,0.00004877668,0.00002936754,0.00001385974,0.00008717195,0.000001903941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002574019,"about_ca_system_score_gemma":0.00001305253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002731188,"about_ca_topic_score_gemma":0.00000332143,"domain_scores_codex":[0.9995765,0.00001186374,0.0001540025,0.0001050075,0.00007037256,0.00008227063],"domain_scores_gemma":[0.9997638,0.00001946289,0.00006168037,0.0001071357,0.00003599089,0.00001195158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007089906,0.00008960165,0.0003460627,0.00008622176,0.000003895138,4.79365e-7,0.00005600461,0.000008774133,0.9978631,0.000003868899,0.0001816411,0.001289506],"study_design_scores_gemma":[0.0002091145,0.00002824563,0.0009761106,0.00004141235,0.00001723948,0.000001857414,0.0001030002,0.0001026685,0.9980806,0.00001830572,0.0003832729,0.00003819221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998243,0.0002034825,0.00001088418,0.0001452635,0.00006119771,0.0001523872,0.000008035541,0.000006124729,0.001169656],"genre_scores_gemma":[0.999235,0.00004299221,0.0004863843,0.00001044152,0.00007460322,0.000001205754,0.00001077587,0.000006552962,0.000131989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251313,"threshold_uncertainty_score":0.1468321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03973199553138006,"score_gpt":0.2474898629185781,"score_spread":0.2077578673871981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}