{"id":"W2133558658","doi":"10.1074/jbc.275.10.7109","title":"Binding of an Antibody Mimetic of the Human Low Density Lipoprotein Receptor to Apolipoprotein E Is Governed through Electrostatic Forces","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Institute for Biological Sciences; University of Ottawa","funders":"National Heart, Lung, and Blood Institute","keywords":"LDL receptor; Apolipoprotein E; Epitope; Chemistry; Receptor; Lipoprotein; Low-density lipoprotein; Ligand (biochemistry); Binding site; Monoclonal antibody; Apolipoprotein B; Antibody; Biochemistry; Biology; Genetics; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243295,0.0002965005,0.0002931827,0.0001233024,0.0001407059,0.0002781046,0.0003946567,0.0003294519,0.0007256801],"category_scores_gemma":[0.0002647222,0.0001763902,0.0002323472,0.00009515532,0.0001581523,0.0001294815,0.0002007372,0.0002778131,0.0003236601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000397864,"about_ca_system_score_gemma":0.0001004837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003549495,"about_ca_topic_score_gemma":0.0003364442,"domain_scores_codex":[0.9997692,0.00005143838,0.00001277369,0.00004379976,0.00007408058,0.0000487038],"domain_scores_gemma":[0.9999459,0.00001564075,0.00001218226,0.000006620538,0.000008052704,0.00001156886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126354,0.0000538638,0.0003366602,0.00001698336,0.000007880594,0.00006697911,0.00000892813,0.0001723641,0.9980099,0.0001411188,0.00003950456,0.001033177],"study_design_scores_gemma":[0.00006577742,0.0007106147,0.002775779,0.000003354605,0.00001501332,0.0007166428,0.00001354221,0.005030872,0.987327,0.00008993255,0.003244463,0.000006859153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964266,0.0003441993,0.002586248,0.00002511478,0.00001158613,0.00002536521,0.0000296834,0.00002260696,0.0005284408],"genre_scores_gemma":[0.9940025,0.0002439021,0.004156993,0.00006279547,0.000006932901,0.00002810196,0.0001890683,0.000007804182,0.001301912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007256801,"threshold_uncertainty_score":0.002886713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160367289148378,"score_gpt":0.2754423632775023,"score_spread":0.2638386903860185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}