{"id":"W2133633698","doi":"10.1039/c3cc47807f","title":"Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges","year":2013,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Cysteine; Intramolecular force; Disulfide bond; Cyclic peptide; Peptide; Chain (unit); Polymer; Polystyrene; Topology (electrical circuits); Chemistry; Polymer chemistry; Sequence (biology); Materials science; Stereochemistry; Organic chemistry; Biochemistry; Mathematics; Combinatorics; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005570518,0.0001626883,0.0001917466,0.00002242606,0.0001642191,0.00005993043,0.0008129076,0.0001488105,0.000239443],"category_scores_gemma":[0.000169235,0.0001520708,0.0001600396,0.0001201148,0.0004042179,0.000008281977,0.0005535094,0.0001286167,0.00007261343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003354219,"about_ca_system_score_gemma":0.00001394346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002533424,"about_ca_topic_score_gemma":0.0000111471,"domain_scores_codex":[0.9990176,0.0000655482,0.0002711793,0.0002805053,0.0001065887,0.0002585828],"domain_scores_gemma":[0.998405,0.0001111587,0.00008070222,0.001198008,0.00008396187,0.0001211441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003981418,0.0002134595,0.0003963848,0.000004750752,0.00004621859,6.292273e-8,0.00001011964,4.378912e-7,0.9697346,0.0001710622,0.02831302,0.001105877],"study_design_scores_gemma":[0.0001487221,0.00001830337,0.0002963651,0.000009266472,0.00002865399,0.000003289992,0.0001112958,0.0001375628,0.9778802,0.0003505062,0.02080791,0.0002079702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780636,0.003588445,0.0005928016,0.01197158,0.0000119742,0.0001535578,0.0000777712,0.0000550335,0.00548524],"genre_scores_gemma":[0.9944311,0.0002553974,0.001464767,0.0008607845,0.00005962234,0.00009443799,0.001701579,0.00002011977,0.001112163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01636753,"threshold_uncertainty_score":0.6201265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02523094755845693,"score_gpt":0.2601013529515826,"score_spread":0.2348704053931257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}