{"id":"W2133694998","doi":"10.1093/hmg/ddu150","title":"Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty","year":2014,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; Turun Yliopistosäätiö; Freistaat Sachsen; Turun Yliopistollinen Keskussairaala; National Health and Medical Research Council; Lastentautien Tutkimussäätiö; Emil Aaltosen Säätiö; Juho Vainion Säätiö; Tampereen Tuberkuloosisäätiö; Deutsche Forschungsgemeinschaft; Kela; Suomen Kulttuurirahasto; ZonMw; Raine Medical Research Foundation; Paavo Nurmen Säätiö; University of Bristol; Curtin University of Technology; Ministerio de Ciencia e Innovación; European Commission; Academy of Finland; European Regional Development Fund; Women and Infants Research Foundation; National Institute for Health and Care Research; Wellcome Trust; University College London; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation International","keywords":"Biology; Menarche; Genome-wide association study; Sexual differentiation; Sexual maturity; Genetics; Endocrinology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001967814,0.0005181378,0.0009236297,0.000925536,0.0004671706,0.00133643,0.0006011893,0.0006101313,0.00442403],"category_scores_gemma":[0.003686076,0.0002958646,0.001568438,0.001701351,0.0005164809,0.0003890872,0.0008641944,0.00102648,0.000430104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562184,"about_ca_system_score_gemma":0.0003837289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003775703,"about_ca_topic_score_gemma":0.005797163,"domain_scores_codex":[0.9987314,0.0003632467,0.000101332,0.0005459394,0.0001696351,0.0000883658],"domain_scores_gemma":[0.9972048,0.001305623,0.0007454724,0.0004027195,0.0001758641,0.0001655008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009033539,0.00004488373,0.9381968,0.0006777309,0.008724412,0.000486909,0.0001982767,0.0003065217,0.005066356,0.0007520547,0.001910581,0.04273213],"study_design_scores_gemma":[0.00002672573,0.00007403587,0.9927639,0.00009509233,0.001995797,0.0005889853,0.00009805766,0.0002769022,0.000347181,0.0006113166,0.003111884,0.0000100357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8007214,0.1731787,0.008156292,0.004162757,0.0005432663,0.00003525474,0.005887578,0.0002678097,0.007047046],"genre_scores_gemma":[0.9809976,0.0135473,0.001922192,0.0007442998,0.0003000361,0.00001541398,0.001633094,0.00005054786,0.0007894001],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00442403,"threshold_uncertainty_score":0.01479989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751049152874372,"score_gpt":0.3131066321065926,"score_spread":0.2855961405778489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}