{"id":"W2133694998","doi":"10.1093/hmg/ddu150","title":"Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty","year":2014,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; Turun Yliopistosäätiö; Freistaat Sachsen; Turun Yliopistollinen Keskussairaala; National Health and Medical Research Council; Lastentautien Tutkimussäätiö; Emil Aaltosen Säätiö; Juho Vainion Säätiö; Tampereen Tuberkuloosisäätiö; Deutsche Forschungsgemeinschaft; Kela; Suomen Kulttuurirahasto; ZonMw; Raine Medical Research Foundation; Paavo Nurmen Säätiö; University of Bristol; Curtin University of Technology; Ministerio de Ciencia e Innovación; European Commission; Academy of Finland; European Regional Development Fund; Women and Infants Research Foundation; National Institute for Health and Care Research; Wellcome Trust; University College London; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation International","keywords":"Biology; Menarche; Genome-wide association study; Sexual differentiation; Sexual maturity; Genetics; Endocrinology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003830498,0.0003262196,0.0008064284,0.0002411666,0.00005752714,0.00005043614,0.0001834658,0.0004223387,0.000006241274],"category_scores_gemma":[0.0001023184,0.0003034786,0.00008565335,0.0001276308,0.00006911821,0.000004503863,0.0001346473,0.0001476941,8.213489e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003298198,"about_ca_system_score_gemma":0.00004797841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000190482,"about_ca_topic_score_gemma":0.0003487552,"domain_scores_codex":[0.9979215,0.0002732615,0.0007983911,0.0005456606,0.0001945509,0.0002665945],"domain_scores_gemma":[0.9990578,0.00009181876,0.0004120018,0.0002768781,0.00008871033,0.00007279323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001332352,0.01067419,0.2148615,0.1208176,0.005232515,0.0003608573,0.007047617,0.0005830776,0.2104324,0.00287118,0.001061902,0.4247249],"study_design_scores_gemma":[0.007387363,0.0101371,0.2091532,0.001821319,0.001843508,0.00004390401,0.003219967,0.0001664033,0.003200351,0.00233884,0.7577571,0.002930962],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5996211,0.3992585,0.00004093722,0.00002531721,0.00002035292,0.0008705197,0.00002158485,0.000003418287,0.0001383382],"genre_scores_gemma":[0.3670923,0.6309029,0.0004102374,0.00004607824,0.00008872545,0.0001960717,0.0004221912,0.00004733675,0.0007940689],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7566952,"threshold_uncertainty_score":0.9999417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751049152874372,"score_gpt":0.3131066321065926,"score_spread":0.2855961405778489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}