{"id":"W2133710289","doi":"10.1002/mds.24997","title":"Trial designs used to study neuroprotective therapy in Parkinson's disease","year":2012,"lang":"en","type":"review","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Neuroprotection; Parkinson's disease; Disease; Clinical trial; Confounding; Medicine; Clinical study design; Physical medicine and rehabilitation; Intensive care medicine; Physical therapy; Psychology; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02740667,0.001241896,0.005538628,0.00288389,0.0003806005,0.001899505,0.001428273,0.002598616,0.002999538],"category_scores_gemma":[0.03588743,0.0005076954,0.002508158,0.004444789,0.001296655,0.00126485,0.001055092,0.002386303,0.0005082837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001195211,"about_ca_system_score_gemma":0.002219397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005786689,"about_ca_topic_score_gemma":0.001017703,"domain_scores_codex":[0.9810906,0.01366229,0.00261048,0.001005028,0.00149079,0.0001408786],"domain_scores_gemma":[0.9557729,0.03905671,0.003083919,0.0007363187,0.001143831,0.0002062905],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002730548,0.0001434347,0.0008121388,0.1892913,0.004904648,0.0001838984,0.0001677243,0.00119137,0.001310398,0.01582507,0.00599383,0.7774456],"study_design_scores_gemma":[0.01406923,0.008099068,0.009854385,0.3084889,0.02685427,0.003554038,0.0004659548,0.001920582,0.004638165,0.05188568,0.5698334,0.0003363083],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003549431,0.996366,0.001496709,0.0004148868,0.0002898488,0.0003369569,0.00005616533,0.000009721547,0.000674653],"genre_scores_gemma":[0.007889351,0.9792728,0.008750611,0.001302481,0.0004546466,0.001798338,0.00008725769,0.00001302751,0.000431368],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9725933,"threshold_uncertainty_score":0.144942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1185436833329114,"score_gpt":0.3601984573533535,"score_spread":0.2416547740204421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}