{"id":"W2133718742","doi":"10.1093/infdis/jis622","title":"A Phase II Study of DAS181, a Novel Host Directed Antiviral for the Treatment of Influenza Infection","year":2012,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; National Institutes of Health","keywords":"Placebo; Viral load; Medicine; Clinical trial; Viral shedding; Pandemic; Influenza A virus; Virology; Internal medicine; Immunology; Virus; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002153231,0.001319903,0.001553465,0.0004747004,0.0004683602,0.0007048858,0.0007941456,0.001165277,0.004844725],"category_scores_gemma":[0.00106743,0.0005789315,0.0008457288,0.0002918338,0.0008284023,0.0006489522,0.000329685,0.002344762,0.0008385537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005392652,"about_ca_system_score_gemma":0.002031413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920205,"about_ca_topic_score_gemma":0.0009284119,"domain_scores_codex":[0.9994104,0.0003091236,0.00003794683,0.00008481374,0.0000663398,0.00009131185],"domain_scores_gemma":[0.9992678,0.0001222744,0.0001593082,0.00005951532,0.00007248096,0.0003187347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7789401,0.07838763,0.005522345,0.001423346,0.0009109185,0.000262814,0.000291246,0.001463781,0.04487009,0.0005412993,0.005338419,0.08204792],"study_design_scores_gemma":[0.7321476,0.260295,0.002576696,0.00002809638,0.0001535624,0.0001477955,0.00002439911,0.0004330566,0.002395191,0.0001176163,0.001667622,0.00001330329],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823156,0.003047135,0.001553572,0.000785038,0.0002892273,0.008508377,0.001420364,0.0001038086,0.001976937],"genre_scores_gemma":[0.9692239,0.003062041,0.005764084,0.001726798,0.0004523695,0.01348467,0.002529594,0.00003375786,0.003722763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004844725,"threshold_uncertainty_score":0.01620722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08304027970620025,"score_gpt":0.4158943236836886,"score_spread":0.3328540439774884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}