{"id":"W2133718742","doi":"10.1093/infdis/jis622","title":"A Phase II Study of DAS181, a Novel Host Directed Antiviral for the Treatment of Influenza Infection","year":2012,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; National Institutes of Health","keywords":"Placebo; Viral load; Medicine; Clinical trial; Viral shedding; Pandemic; Influenza A virus; Virology; Internal medicine; Immunology; Virus; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005598026,0.0001938598,0.0005640653,0.0002414286,0.0003477199,0.000009413863,0.0001021094,0.00003609128,0.00001615229],"category_scores_gemma":[0.0009909839,0.00009132802,0.0003099331,0.0003801776,0.0002236843,0.0001940635,0.00005127144,0.0001321663,0.000001112647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631092,"about_ca_system_score_gemma":0.0001833681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580227,"about_ca_topic_score_gemma":0.00007270632,"domain_scores_codex":[0.9983637,0.0001633233,0.0006265989,0.00007716503,0.0004782775,0.00029088],"domain_scores_gemma":[0.9971303,0.0009694154,0.0006655401,0.0003012143,0.0008155247,0.0001179603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01339415,0.09200054,0.8269004,0.0002238964,0.00566815,0.000004584048,0.01723008,0.0001533751,0.02895402,0.00003275377,0.0006151941,0.01482281],"study_design_scores_gemma":[0.04996234,0.09264875,0.8305132,0.0002197709,0.0063723,0.0001055187,0.002695888,0.0001691177,0.01210677,0.00002470632,0.004988937,0.0001926776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993257,0.004672945,0.0001335603,0.00005762133,0.0002140418,0.001476691,0.00007127551,0.00002508263,0.00009171844],"genre_scores_gemma":[0.9983357,0.001077295,0.00001335302,0.00006282679,0.0004075753,0.00005156697,0.000001165063,0.00002105439,0.0000295221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03656819,"threshold_uncertainty_score":0.3724249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08304027970620025,"score_gpt":0.4158943236836886,"score_spread":0.3328540439774884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}