{"id":"W2133727168","doi":"10.1128/iai.01771-14","title":"Giardia duodenalis Cathepsin B Proteases Degrade Intestinal Epithelial Interleukin-8 and Attenuate Interleukin-8-Induced Neutrophil Chemotaxis","year":2014,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biology; Giardia; Proteases; Chemotaxis; Microbiology; Cathepsin B; Cathepsin; Immunology; Interleukin 8; Intestinal mucosa; Interleukin; Interleukin 2; Cathepsin L1; Intestinal epithelium; Immune system; Epithelium; Inflammation; Cytokine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004165443,0.0002748875,0.0003337531,0.0001932954,0.0006149825,0.00007761946,0.00009322314,0.0002320173,0.0001454229],"category_scores_gemma":[0.0008623505,0.0002466285,0.00009243232,0.0001515082,0.0003536723,0.0001708228,0.0001461576,0.0006301924,0.0001593272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005757207,"about_ca_system_score_gemma":0.0000393765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004936705,"about_ca_topic_score_gemma":0.0002340809,"domain_scores_codex":[0.9985533,0.0004552931,0.0003262656,0.0003016054,0.00003663806,0.0003268502],"domain_scores_gemma":[0.9989686,0.0003854078,0.000145711,0.0002985545,0.000137638,0.00006407356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004565275,0.0007835616,0.1644623,0.0001262445,0.0003632314,0.00001011673,0.00191456,0.000007694354,0.7424709,0.002744521,0.000994183,0.08566617],"study_design_scores_gemma":[0.003432639,0.002061744,0.7138855,0.0002712788,0.0002230651,0.002101187,0.0001628373,0.0001660515,0.244371,0.001210057,0.03135376,0.0007608793],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956264,0.0001690551,0.001473306,0.0002093006,0.0008568244,0.0002716858,0.00002207019,0.0001424849,0.001228799],"genre_scores_gemma":[0.9991116,0.0001368679,0.00007767489,0.0002400821,0.0000972497,0.00005062448,0.00004906479,0.00002059258,0.0002162236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5494232,"threshold_uncertainty_score":0.9999986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146360244602171,"score_gpt":0.2450797735954107,"score_spread":0.2304437491351936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}