{"id":"W2133741696","doi":"10.1177/1087057109357117","title":"Assessing the Stability of Membrane Proteins to Detect Ligand Binding Using Differential Static Light Scattering","year":2010,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Ontario Ministry of Research and Innovation; Novartis Foundation; Stiftelsen för Strategisk Forskning; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Merck; Ontario Innovation Trust; Ontario Genomics Institute","keywords":"Membrane protein; ATP-binding cassette transporter; Ligand (biochemistry); Chemistry; Membrane; Biophysics; Biochemistry; Transporter; Biology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122791,0.0007934425,0.00055302,0.0008373556,0.0006887242,0.0008504392,0.0005171083,0.0009988486,0.001755351],"category_scores_gemma":[0.001141676,0.0003681323,0.0006719012,0.0006744379,0.0005466953,0.0006642919,0.0006529217,0.00171649,0.00120043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001237072,"about_ca_system_score_gemma":0.0006160742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001747687,"about_ca_topic_score_gemma":0.002048622,"domain_scores_codex":[0.9983718,0.0002519232,0.000136685,0.0004002941,0.0006777457,0.0001615804],"domain_scores_gemma":[0.9988391,0.0002491513,0.0002084747,0.0001160562,0.0005028802,0.00008445026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001971345,0.00001724223,0.0001511915,0.0000529347,0.000008324807,0.00001960696,0.00003684549,0.00009799487,0.997541,0.0001445879,0.00008457222,0.001826132],"study_design_scores_gemma":[0.000003349922,0.00007774898,0.0007849819,0.00000788326,0.000009700144,0.00006654688,0.00003986092,0.001432936,0.9944418,0.0001017547,0.00302019,0.00001315974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7424092,0.0064009,0.235008,0.001492633,0.0004981859,0.0003623671,0.001108986,0.001798561,0.01092117],"genre_scores_gemma":[0.804728,0.007666576,0.1617125,0.0011006,0.0001016967,0.0006813142,0.00259933,0.0004352925,0.02097486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755351,"threshold_uncertainty_score":0.008975565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215162718036127,"score_gpt":0.2976357300137145,"score_spread":0.2761194582101018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}