{"id":"W2133752479","doi":"10.1093/cvr/cvq254","title":"A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1–calcineurin pathway","year":2010,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Canadian Institutes of Health Research; Mayo Foundation for Medical Education and Research; Heart and Stroke Foundation of Canada","keywords":"Calcineurin; NFAT; Internal medicine; Endocrinology; Sodium–hydrogen antiporter; Chemistry; Muscle hypertrophy; Angiotensin II; Myocyte; Natriuretic peptide; Atrial natriuretic peptide; Biology; Biochemistry; Sodium; Receptor; Medicine; Heart failure; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679359,0.0002582887,0.0002874523,0.00008708629,0.000115106,0.0001735509,0.0003001704,0.0003525658,0.0007357492],"category_scores_gemma":[0.0001359947,0.0000797488,0.0001776758,0.00006838693,0.0002621818,0.0002130343,0.0001468862,0.0005110713,0.0001063892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277096,"about_ca_system_score_gemma":0.0001909145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000247705,"about_ca_topic_score_gemma":0.0003775874,"domain_scores_codex":[0.9998839,0.00002012736,0.0000103907,0.00003775355,0.00002573724,0.00002206646],"domain_scores_gemma":[0.9998764,0.00002167758,0.00004214788,0.00001159423,0.00001326252,0.00003488544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001318164,0.00003915626,0.00006448945,0.00002839213,0.000003408269,0.00002872924,0.000006218725,0.00003835312,0.999022,0.00003312271,0.0000160478,0.0005882534],"study_design_scores_gemma":[0.0001307674,0.002176314,0.004702282,0.00001043552,0.00004443445,0.0006637215,0.00002510324,0.001467169,0.9882389,0.00003836401,0.002494112,0.000008458324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967747,0.0007338499,0.001904699,0.00006144441,0.00003052436,0.00002652376,0.00008248733,0.00004320483,0.0003424405],"genre_scores_gemma":[0.9942923,0.0005106824,0.004003332,0.00006882506,0.00001962684,0.00005250726,0.0002404683,0.00001392076,0.0007983493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007357492,"threshold_uncertainty_score":0.002461374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06736576734910091,"score_gpt":0.3364031547378483,"score_spread":0.2690373873887474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}