{"id":"W2133752479","doi":"10.1093/cvr/cvq254","title":"A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1–calcineurin pathway","year":2010,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Canadian Institutes of Health Research; Mayo Foundation for Medical Education and Research; Heart and Stroke Foundation of Canada","keywords":"Calcineurin; NFAT; Internal medicine; Endocrinology; Sodium–hydrogen antiporter; Chemistry; Muscle hypertrophy; Angiotensin II; Myocyte; Natriuretic peptide; Atrial natriuretic peptide; Biology; Biochemistry; Sodium; Receptor; Medicine; Heart failure; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002641326,0.00031706,0.0007226173,0.0002562564,0.0005365293,0.0001248765,0.0004325318,0.0001669311,0.0001355439],"category_scores_gemma":[0.0005332407,0.000197558,0.001437011,0.00112246,0.0005716076,0.000131901,0.0003563031,0.00148219,0.0005412665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114129,"about_ca_system_score_gemma":0.0002873912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005465687,"about_ca_topic_score_gemma":0.00001429674,"domain_scores_codex":[0.9954085,0.0003673249,0.0003162717,0.0007640151,0.002184463,0.0009593825],"domain_scores_gemma":[0.9968929,0.0002084004,0.00003148152,0.00215351,0.0004382625,0.0002754848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001222812,0.002429998,0.002209868,0.001107084,0.03166701,0.005086868,0.005607258,0.0003560188,0.6146318,0.01170712,0.1419284,0.1820458],"study_design_scores_gemma":[0.002385008,0.0003013954,0.004924062,0.00005264228,0.0005438175,0.0006785613,0.0005166727,0.00006284881,0.01512922,0.00008483206,0.975073,0.0002479669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9243398,0.01056548,0.0009036282,0.01280728,0.0009749405,0.004065845,0.00001344319,0.000284371,0.04604519],"genre_scores_gemma":[0.9880401,0.0005519375,0.003324926,0.0001832204,0.001456755,0.0004297957,0.00002668805,0.00008747198,0.005899083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8331446,"threshold_uncertainty_score":0.8056179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06736576734910091,"score_gpt":0.3364031547378483,"score_spread":0.2690373873887474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}