{"id":"W2133802070","doi":"10.1681/asn.2009070719","title":"Targeted Inactivation of EGF Receptor Inhibits Renal Collecting Duct Development and Function","year":2010,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal; Université de Montréal; McGill University; Montreal Children's Hospital","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Kidney; Aquaporin 2; Renal medulla; Endocrinology; Knockout mouse; Kidney development; Biology; Internal medicine; Receptor; Receptor tyrosine kinase; Genetically modified mouse; Parenchyma; Transgene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718899,0.0002531583,0.0003220746,0.0002115908,0.0001064059,0.0002979306,0.0002598498,0.0002805221,0.0009082309],"category_scores_gemma":[0.0001466488,0.0001862472,0.0002583821,0.00009317204,0.0002111015,0.0001776834,0.0001392979,0.0005576188,0.0002884871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002595759,"about_ca_system_score_gemma":0.0002657885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006469279,"about_ca_topic_score_gemma":0.001290479,"domain_scores_codex":[0.9997849,0.00003272175,0.00002458391,0.00003468283,0.00005645385,0.00006664144],"domain_scores_gemma":[0.9998026,0.00005237918,0.00004988256,0.0000264172,0.00001488273,0.00005370023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000603022,0.00003379303,0.0001514466,0.00001632973,0.000004606012,0.00003731993,0.00000846743,0.00007440259,0.9983733,0.00009649093,0.00002744261,0.00111607],"study_design_scores_gemma":[0.00001122172,0.0002288319,0.002745212,0.00000314648,0.00001548675,0.0001752406,0.00001597689,0.001082303,0.9945311,0.00002737865,0.001161526,0.000002576897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959493,0.0006889059,0.002128547,0.00005632046,0.00001759951,0.00001448533,0.0001512728,0.0001117919,0.0008818741],"genre_scores_gemma":[0.9953923,0.0004817119,0.0009956756,0.00002554263,0.000003978573,0.00001799629,0.0001886074,0.00002606781,0.002868182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009082309,"threshold_uncertainty_score":0.003038347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007125554998943074,"score_gpt":0.2287719804250452,"score_spread":0.2216464254261022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}