{"id":"W2133873320","doi":"10.1124/mol.109.062679","title":"Correction of the ΔPhe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University","funders":"Canadian Institutes of Health Research; Rosalind Franklin University of Medicine and Science; McGill University","keywords":"Cystic fibrosis transmembrane conductance regulator; Pharmacology; Chemistry; In vivo; Ex vivo; Cystic fibrosis; Cell biology; Molecular biology; In vitro; Biochemistry; Biology; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920866,0.0004957653,0.0006210903,0.0003344868,0.0003130826,0.0003206019,0.0004923414,0.0009109774,0.002416235],"category_scores_gemma":[0.0003862589,0.0001329859,0.0002808906,0.0001550481,0.0005761737,0.0002999041,0.0003294575,0.001233811,0.000693464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002510477,"about_ca_system_score_gemma":0.0004211523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003800084,"about_ca_topic_score_gemma":0.0003014047,"domain_scores_codex":[0.9998201,0.00002924012,0.0000338846,0.0000268541,0.00005837506,0.00003162329],"domain_scores_gemma":[0.9997584,0.00008260841,0.00006170209,0.00002358956,0.00001738912,0.00005626725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001194529,0.00009276102,0.0002979669,0.00013927,0.00001620443,0.006937922,0.00005582435,0.0004764863,0.9718492,0.00135057,0.001205715,0.0163835],"study_design_scores_gemma":[0.0008547271,0.0015552,0.002566637,0.00003592195,0.00007466899,0.01643334,0.00008360264,0.003397769,0.9545339,0.001083773,0.01933432,0.00004618447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978038,0.001958161,0.009225912,0.005196029,0.001049714,0.00008311684,0.0006419158,0.0007787534,0.003028436],"genre_scores_gemma":[0.9926443,0.001091289,0.002884637,0.0002479251,0.0001572564,0.00002635131,0.0002397417,0.0001030251,0.002605435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002416235,"threshold_uncertainty_score":0.008083045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008611892832236987,"score_gpt":0.2889855658781945,"score_spread":0.2803736730459575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}