{"id":"W2133890709","doi":"10.1093/hmg/dds397","title":"A fully humanized transgenic mouse model of Huntington disease","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Huntington Society of Canada; CHDI Foundation; Michael Smith Health Research BC; Pfizer","keywords":"Huntingtin; Biology; Huntington's disease; Gene silencing; Humanized mouse; Transgene; Genetics; Mutation; Allele; Loss of heterozygosity; Genetically modified mouse; Trinucleotide repeat expansion; Gene knockin; Gene; Disease; Mutant; Medicine; In vivo; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006489661,0.00110562,0.0006935919,0.001155518,0.0005489536,0.0005677327,0.001127604,0.001723494,0.007731611],"category_scores_gemma":[0.0002014906,0.0005011115,0.0005721606,0.0005099382,0.0006285605,0.000678808,0.0004186702,0.001898856,0.00271406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005667642,"about_ca_system_score_gemma":0.0005548815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008304244,"about_ca_topic_score_gemma":0.001471489,"domain_scores_codex":[0.9994842,0.00005263777,0.00006201642,0.000169449,0.0001571638,0.00007458113],"domain_scores_gemma":[0.9996908,0.00003216617,0.0000836976,0.00005319006,0.00004738702,0.00009285168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007331469,0.000549313,0.0003202794,0.0001197607,0.00004895151,0.0004902013,0.00009511642,0.0002304081,0.9872546,0.001796204,0.00226867,0.006093471],"study_design_scores_gemma":[0.00125893,0.005521785,0.007809,0.0001723408,0.0003392413,0.007886348,0.0001339209,0.005216377,0.8427748,0.001725494,0.1270612,0.0001004878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.846048,0.004853744,0.08946831,0.002622239,0.001383677,0.001927347,0.02933298,0.004084831,0.02027888],"genre_scores_gemma":[0.7741792,0.007200764,0.09191766,0.001549587,0.0003446732,0.003696249,0.02812534,0.000780407,0.09220614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007731611,"threshold_uncertainty_score":0.02586484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04952742844396621,"score_gpt":0.2837237723406116,"score_spread":0.2341963438966454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}