{"id":"W2133909380","doi":"10.1128/aac.01828-09","title":"HIV-1 Protease Codon 36 Polymorphisms and Differential Development of Resistance to Nelfinavir, Lopinavir, and Atazanavir in Different HIV-1 Subtypes","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Virology; Biology; Nelfinavir; Protease; Lopinavir; Virus; Viral replication; Drug resistance; Genetics; Viral load; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002123858,0.0001710818,0.0002018196,0.0003489206,0.0001785033,0.000246451,0.0001389903,0.0003040536,0.0005300064],"category_scores_gemma":[0.0004136932,0.0001921267,0.000270374,0.0002007437,0.0001865521,0.0001288484,0.0001224778,0.0003394694,0.0001170432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000163055,"about_ca_system_score_gemma":0.0001098562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298991,"about_ca_topic_score_gemma":0.001016284,"domain_scores_codex":[0.9997901,0.00004253238,0.00002226263,0.00005927097,0.00003061664,0.00005514918],"domain_scores_gemma":[0.9997752,0.00005572477,0.00006622796,0.00002452022,0.00001759151,0.00006068698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004172803,0.0004236084,0.2848876,0.00003507539,0.0001268268,0.0008973282,0.0005834219,0.0002704123,0.7004494,0.0001523805,0.0001277795,0.007873404],"study_design_scores_gemma":[0.00004470692,0.001325483,0.9769697,0.000005814298,0.0000386398,0.002564024,0.000190796,0.0005261469,0.01799445,0.00004522317,0.0002821813,0.00001283162],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998134,0.00004473991,0.0000238195,0.000002905384,6.795407e-7,0.000002737588,0.00003390008,9.638457e-7,0.00007693363],"genre_scores_gemma":[0.9996367,0.00003181099,0.00008642013,0.0000104314,0.000001861597,0.000004314751,0.0001042115,0.000001931223,0.0001222874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298991,"threshold_uncertainty_score":0.002582788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063260683702585,"score_gpt":0.2453215488864529,"score_spread":0.2346889420494271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}