{"id":"W2133919090","doi":"10.1186/1742-4690-10-96","title":"The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication","year":2013,"lang":"en","type":"article","venue":"Retrovirology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Faculty of Medicine, McGill University; McGill University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Protein kinase R; Pact; Activator (genetics); Interferon; EIF-2 kinase; Biology; Small hairpin RNA; Molecular biology; Viral replication; Protein kinase A; Antiviral protein; Cell biology; RNA; Phosphorylation; Virology; Virus; Cyclin-dependent kinase 2; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723714,0.0003336676,0.0003920046,0.0001906882,0.0002397017,0.000662656,0.0002757206,0.0003531112,0.002301816],"category_scores_gemma":[0.0003156017,0.0002093155,0.0002385433,0.0001822131,0.0002508584,0.0004500662,0.0002043619,0.0009574153,0.0007148175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391417,"about_ca_system_score_gemma":0.0002085036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001534005,"about_ca_topic_score_gemma":0.0001940706,"domain_scores_codex":[0.9997688,0.00002921348,0.00002140188,0.0000617418,0.00006701338,0.00005176571],"domain_scores_gemma":[0.9998574,0.00003476628,0.00004257842,0.00001828557,0.00001709447,0.00002991964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003190066,0.00005286411,0.0002268793,0.00009988933,0.000007045193,0.00008593204,0.00001572686,0.00006637946,0.9965404,0.0001167574,0.0000963736,0.002372835],"study_design_scores_gemma":[0.00003089977,0.0003149436,0.003405842,0.00001393899,0.00002520249,0.0006492006,0.00002108842,0.000842867,0.990694,0.00009439608,0.003901219,0.000006522206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781711,0.01409684,0.003305966,0.0002965327,0.0001910844,0.00007868823,0.0006133295,0.0001616423,0.003084879],"genre_scores_gemma":[0.988632,0.003243426,0.003664394,0.0001215867,0.00008077616,0.00007581079,0.001035515,0.00004576716,0.003100709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002301816,"threshold_uncertainty_score":0.007700324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005261296341085971,"score_gpt":0.2267331645317724,"score_spread":0.2214718681906864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}