{"id":"W2133919090","doi":"10.1186/1742-4690-10-96","title":"The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication","year":2013,"lang":"en","type":"article","venue":"Retrovirology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Faculty of Medicine, McGill University; McGill University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Protein kinase R; Pact; Activator (genetics); Interferon; EIF-2 kinase; Biology; Small hairpin RNA; Molecular biology; Viral replication; Protein kinase A; Antiviral protein; Cell biology; RNA; Phosphorylation; Virology; Virus; Cyclin-dependent kinase 2; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009043825,0.0001127988,0.0000931812,0.00002790489,0.0001875101,0.00003758326,0.0001639839,0.0001463037,0.00009074629],"category_scores_gemma":[0.0001954296,0.00008401223,0.00007773675,0.00005640903,0.0001085406,0.000007633596,0.00008741598,0.00007674158,0.0001599973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001981248,"about_ca_system_score_gemma":0.00003872776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001442473,"about_ca_topic_score_gemma":0.000007050476,"domain_scores_codex":[0.9990968,0.00007980329,0.0001735572,0.0003265208,0.00008325662,0.0002400907],"domain_scores_gemma":[0.999039,0.00002354014,0.00009833397,0.0006769751,0.00005580111,0.000106327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001112124,0.0000368275,0.05191087,0.000007244051,0.00003299215,0.000001102958,0.00001586446,0.00001077161,0.9331267,0.0002804789,0.01205965,0.002406308],"study_design_scores_gemma":[0.0009010332,0.0001755039,0.7517532,0.00000321557,0.0000156659,0.00003014395,0.0000630479,0.0001316354,0.13443,0.0003298121,0.1119458,0.0002209526],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949269,0.0003098886,0.0001030916,0.003446219,0.0001182619,0.0002095759,0.000005504669,0.00002542098,0.0008551477],"genre_scores_gemma":[0.9949738,0.0001009371,0.00005554163,0.0004752809,0.0003092415,0.00008178091,0.00006449784,0.00001727911,0.00392164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7986966,"threshold_uncertainty_score":0.3425919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005261296341085971,"score_gpt":0.2267331645317724,"score_spread":0.2214718681906864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}