{"id":"W2133950160","doi":"10.1128/aac.00985-13","title":"Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Isothermal titration calorimetry; Capsid; Binding site; Viral replication; Small molecule; Biology; Reverse transcriptase; Transcription factor; Viral protein; Stereochemistry; Molecular biology; Chemistry; Virology; Biophysics; Biochemistry; Virus; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007442012,0.0001680063,0.0002434255,0.00005916136,0.0001163297,0.00004097803,0.0001358942,0.0001102059,0.0003576592],"category_scores_gemma":[0.00001113462,0.0001310871,0.00008270607,0.0000716465,0.0002530832,0.0001326981,0.00005579078,0.00009833684,0.0001410415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002046864,"about_ca_system_score_gemma":0.00002923621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007018281,"about_ca_topic_score_gemma":0.00002321045,"domain_scores_codex":[0.9990789,0.00004171352,0.0002165466,0.0003404971,0.00003564243,0.000286684],"domain_scores_gemma":[0.9994328,0.00004378844,0.0001069194,0.000333574,0.00005551158,0.00002741817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008260569,0.0005395459,0.02933062,0.00002942544,0.0001710429,0.000001032328,0.0002920218,2.905722e-7,0.9338633,0.00005693129,0.03329924,0.002333959],"study_design_scores_gemma":[0.0031116,0.0001693358,0.07057441,0.00004172675,0.00001711131,0.00002720956,0.0001198579,0.000003146806,0.9142247,0.00001472045,0.01152516,0.0001709758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996722,0.0001267506,0.0001673155,0.001928465,0.00007860688,0.0004779455,0.0001766675,0.00002483628,0.0002973411],"genre_scores_gemma":[0.9960721,0.000468747,0.0001787575,0.0007998816,0.0000179242,0.00002540349,0.0003916085,0.00001929073,0.002026336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04124379,"threshold_uncertainty_score":0.5345579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682619387481969,"score_gpt":0.2599903977843095,"score_spread":0.2331642039094898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}