{"id":"W2133950160","doi":"10.1128/aac.00985-13","title":"Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Isothermal titration calorimetry; Capsid; Binding site; Viral replication; Small molecule; Biology; Reverse transcriptase; Transcription factor; Viral protein; Stereochemistry; Molecular biology; Chemistry; Virology; Biophysics; Biochemistry; Virus; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486178,0.0003533239,0.0003065261,0.0001601341,0.0001020178,0.0004349097,0.0003098297,0.0002320558,0.0007325784],"category_scores_gemma":[0.0001424084,0.0001526334,0.0001417274,0.00009781693,0.0001403727,0.0001942785,0.0001540967,0.0004746155,0.0002569704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003561844,"about_ca_system_score_gemma":0.0001738577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000248497,"about_ca_topic_score_gemma":0.0007921076,"domain_scores_codex":[0.9999399,0.000007897416,0.000003677869,0.00001236721,0.00002171731,0.00001437539],"domain_scores_gemma":[0.9999528,0.000009061166,0.00001325065,0.00000435602,0.000008498031,0.00001212759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001563799,0.0001199478,0.0002415626,0.0001445655,0.00001907599,0.0000767621,0.00001842189,0.0007942881,0.978934,0.0007749638,0.0002767837,0.01844324],"study_design_scores_gemma":[0.0003823578,0.002773089,0.003563712,0.00003100025,0.00006632468,0.0005961251,0.00002170352,0.006561154,0.9526503,0.00036917,0.03295598,0.00002905252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432381,0.02991679,0.0188919,0.0004626232,0.0001385274,0.0004321585,0.0006341917,0.0004685651,0.005817151],"genre_scores_gemma":[0.9746542,0.008842338,0.01163014,0.0001521107,0.00004168967,0.0001417905,0.0007976534,0.00002297308,0.003717094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007325784,"threshold_uncertainty_score":0.002584279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682619387481969,"score_gpt":0.2599903977843095,"score_spread":0.2331642039094898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}