{"id":"W2133952476","doi":"10.1128/jvi.01604-09","title":"Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Brookhaven National Laboratory; Canadian Institutes of Health Research","keywords":"Epitope; Gp41; Immunogen; Biology; Monoclonal antibody; Virology; Antibody; Amino acid; Neutralizing antibody; Peptide sequence; Virus; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556963,0.0002940168,0.0002877259,0.0001272399,0.0002624321,0.0004454759,0.0004921833,0.0003955094,0.001341419],"category_scores_gemma":[0.000221202,0.0001569309,0.0001479578,0.0001850185,0.0002275017,0.000361425,0.0001353662,0.0006827488,0.0002628108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007830794,"about_ca_system_score_gemma":0.0005347729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004327732,"about_ca_topic_score_gemma":0.003976645,"domain_scores_codex":[0.999939,0.00001198915,0.000003729191,0.00001004664,0.00002192518,0.00001337277],"domain_scores_gemma":[0.9999553,0.000008595266,0.0000102662,0.000003761047,0.00001037813,0.00001167622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001020158,0.000416848,0.006858221,0.000708578,0.00006365293,0.00139319,0.0005122127,0.03281219,0.8912281,0.02427877,0.005157638,0.0355505],"study_design_scores_gemma":[0.0007558269,0.001119525,0.02966805,0.0002516774,0.000152795,0.00313993,0.001056892,0.2083022,0.6437339,0.008344337,0.10336,0.0001148877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542062,0.007278138,0.01947113,0.001164001,0.000123274,0.00008192037,0.0009581312,0.0001504096,0.01656676],"genre_scores_gemma":[0.9750218,0.003079945,0.01784328,0.0003092525,0.00002903883,0.00004580175,0.001504531,0.0000195418,0.002146823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004327732,"threshold_uncertainty_score":0.008605123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03576041374811042,"score_gpt":0.3087845281372427,"score_spread":0.2730241143891323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}