{"id":"W2133997825","doi":"10.1073/pnas.0601505103","title":"Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"","keywords":"Random hexamer; Chaperone (clinical); Cofactor; AAA proteins; Cyclic nucleotide-binding domain; Chemistry; Zinc finger; Plasma protein binding; Binding site; Allosteric regulation; Biochemistry; Fluorescence anisotropy; Biophysics; ATPase; Biology; Peptide sequence; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026115,0.0001610731,0.0002067869,0.0001198251,0.0001272236,0.0003780884,0.0002432294,0.0002356473,0.0006442767],"category_scores_gemma":[0.0003195504,0.0001575795,0.000109042,0.0001111538,0.0001928541,0.000226318,0.00027183,0.000259542,0.0003749988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000049,"about_ca_system_score_gemma":0.0001174212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004194673,"about_ca_topic_score_gemma":0.0005243772,"domain_scores_codex":[0.9997646,0.00004201343,0.00001523109,0.00006129415,0.00007794695,0.00003887619],"domain_scores_gemma":[0.9998831,0.00002684489,0.00001765102,0.00001759534,0.000023831,0.00003102991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046613,0.00000809326,0.0009048527,0.00001702973,0.000001943698,0.00003823709,0.00001328166,0.00006465324,0.99749,0.00008522476,0.00002467612,0.001247304],"study_design_scores_gemma":[0.00002173555,0.0001323101,0.03058204,0.000006655947,0.000007770942,0.001262506,0.00009256158,0.004576148,0.9615195,0.0001779729,0.001608766,0.00001190221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959954,0.0005832695,0.00270006,0.00004332427,0.00000400455,0.000004783718,0.00005313621,0.00001744892,0.0005985457],"genre_scores_gemma":[0.99795,0.0001528902,0.00120687,0.00003425026,0.000002306771,0.000004486235,0.0001297278,0.000005085519,0.0005144403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006442767,"threshold_uncertainty_score":0.002155304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03418368582473504,"score_gpt":0.2992585658753752,"score_spread":0.2650748800506402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}