{"id":"W2134054275","doi":"10.1021/bi060142r","title":"Reversible Photocontrol of DNA Binding by a Designed GCN4-bZIP Protein","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"","keywords":"Chromophore; Photoisomerization; Chemistry; DNA; Azobenzene; Coiled coil; Isomerization; bZIP domain; Leucine zipper; Zipper; Biophysics; Crystallography; Photochemistry; Molecule; Biochemistry; Peptide sequence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446131,0.0003492238,0.0003056495,0.00009706078,0.0001620494,0.000181876,0.0003321768,0.0002416096,0.0007298677],"category_scores_gemma":[0.0002117232,0.0001669972,0.0001753372,0.0001218632,0.0003045727,0.0001655923,0.0002000789,0.0004793557,0.0003026261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006384352,"about_ca_system_score_gemma":0.0002826354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005910038,"about_ca_topic_score_gemma":0.001061456,"domain_scores_codex":[0.9998796,0.00001932465,0.000008851545,0.00003990657,0.00003403041,0.00001827],"domain_scores_gemma":[0.9998796,0.00002180507,0.00005144445,0.00001174383,0.000011432,0.00002391078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005258721,0.00001032531,0.00007488018,0.00001956659,0.0000027409,0.00001273104,0.000005554297,0.0001375043,0.9989479,0.00006901721,0.000008903039,0.000658326],"study_design_scores_gemma":[0.000006163172,0.00005952303,0.0003056481,0.000001042999,0.000003871629,0.00005774289,0.000002708422,0.0004835899,0.9984113,0.00001275723,0.0006533347,0.000002209516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860045,0.0006484441,0.01160718,0.00008528942,0.00003227813,0.00007437693,0.0001916567,0.0001552434,0.001200908],"genre_scores_gemma":[0.9758413,0.0003556552,0.02136733,0.00005352346,0.000007787086,0.00006517736,0.0003937436,0.00005119069,0.00186433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007298677,"threshold_uncertainty_score":0.004632235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006231195886965593,"score_gpt":0.2057433110993495,"score_spread":0.1995121152123839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}