{"id":"W2134054275","doi":"10.1021/bi060142r","title":"Reversible Photocontrol of DNA Binding by a Designed GCN4-bZIP Protein","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"","keywords":"Chromophore; Photoisomerization; Chemistry; DNA; Azobenzene; Coiled coil; Isomerization; bZIP domain; Leucine zipper; Zipper; Biophysics; Crystallography; Photochemistry; Molecule; Biochemistry; Peptide sequence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002209552,0.0001954033,0.0002608715,0.00002047964,0.00008174465,0.00003603757,0.0003952136,0.0001860104,0.0006544677],"category_scores_gemma":[0.00006626973,0.0001925399,0.00009005069,0.0001355327,0.000198623,0.00008086219,0.00006288232,0.00009137593,0.00005590346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001008718,"about_ca_system_score_gemma":0.0001386521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001617454,"about_ca_topic_score_gemma":6.580235e-7,"domain_scores_codex":[0.9986202,0.00001736172,0.0003479078,0.0003889741,0.0002642842,0.0003613368],"domain_scores_gemma":[0.9992128,0.0000273786,0.0002238935,0.000385119,0.00006113244,0.00008969771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006149559,0.00009768601,0.0001024837,0.0001761771,0.000004722765,0.000005428187,0.0000114879,4.469707e-7,0.9858774,0.000007256957,0.0136346,0.00002081374],"study_design_scores_gemma":[0.000719664,0.00001794709,0.00001350969,0.000128629,0.00001252912,0.00000796126,0.00004666724,0.00002300631,0.9984713,0.00007234406,0.0002696794,0.0002167424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946507,0.0001443401,0.0001767863,0.00003370306,0.00003723118,0.0004658891,0.0001570314,0.00007477412,0.004259601],"genre_scores_gemma":[0.9935336,0.00000134051,0.001172409,0.00001903,0.0001109757,0.0001618991,0.00005219471,0.00001810266,0.00493042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01336492,"threshold_uncertainty_score":0.7851548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006231195886965593,"score_gpt":0.2057433110993495,"score_spread":0.1995121152123839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}