{"id":"W2134056794","doi":"10.1128/jvi.01865-08","title":"Insertional Gene Activation by Lentiviral and Gammaretroviral Vectors","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Health and Safety Executive","keywords":"Insertional mutagenesis; Biology; Enhancer; Lentivirus; Mutagenesis; Insert (composites); Mutant; Genetic enhancement; Locus (genetics); Gene; Viral vector; Insertion; Molecular biology; Genetics; Virus; Gene expression; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082523,0.00008846256,0.0001339494,0.00008146874,0.00007290237,0.000006079277,0.0001152611,0.0001241887,0.0000347952],"category_scores_gemma":[0.00006158025,0.00007925235,0.00006386259,0.00005068796,0.0001536193,0.000009605241,0.00004084686,0.0001644824,0.000002999237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001868116,"about_ca_system_score_gemma":0.0001025507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003877463,"about_ca_topic_score_gemma":0.000004869798,"domain_scores_codex":[0.9992067,0.0001211893,0.0002114144,0.0001268447,0.0001643298,0.0001694729],"domain_scores_gemma":[0.9995783,0.00001588665,0.0001426854,0.00009582677,0.00009499241,0.00007231602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002314253,0.000062543,0.01177156,0.000001892754,0.00006584176,0.00001062593,0.00002373038,0.00002470088,0.9806114,0.000003571727,0.003961056,0.001148804],"study_design_scores_gemma":[0.001233891,0.006726652,0.02883552,0.000002339309,0.000008046252,0.0003970549,0.000008507164,0.00002019923,0.9558979,0.00006465468,0.006708677,0.00009654103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979504,0.0009088078,0.0005028048,0.0004467668,0.00008543042,0.00004198404,0.000005905236,0.000002012693,0.00005590807],"genre_scores_gemma":[0.9982478,0.0006558839,0.0001450009,0.0004197588,0.0003031849,0.000001772229,0.00002139996,0.00001244385,0.0001927411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02471351,"threshold_uncertainty_score":0.3231817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423606478166952,"score_gpt":0.2658711299349949,"score_spread":0.2516350651533254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}