{"id":"W2134056794","doi":"10.1128/jvi.01865-08","title":"Insertional Gene Activation by Lentiviral and Gammaretroviral Vectors","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Health and Safety Executive","keywords":"Insertional mutagenesis; Biology; Enhancer; Lentivirus; Mutagenesis; Insert (composites); Mutant; Genetic enhancement; Locus (genetics); Gene; Viral vector; Insertion; Molecular biology; Genetics; Virus; Gene expression; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199399,0.0006348856,0.0004614754,0.0009753485,0.000352163,0.001189564,0.0009304747,0.0007975544,0.002906557],"category_scores_gemma":[0.0004894774,0.0004715318,0.0006037257,0.000713282,0.0006031306,0.000491192,0.0007054295,0.002109049,0.002143173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004450686,"about_ca_system_score_gemma":0.0004797847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002581144,"about_ca_topic_score_gemma":0.0003414314,"domain_scores_codex":[0.9985027,0.0002456406,0.0001918774,0.0002431041,0.0006268048,0.0001898506],"domain_scores_gemma":[0.9995869,0.00009789124,0.00009436922,0.0001034126,0.00005784248,0.00005969328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001805813,0.0001088395,0.0002586591,0.0001719127,0.00001533381,0.0001155507,0.00009396377,0.0001470541,0.9750405,0.003528144,0.00071533,0.019624],"study_design_scores_gemma":[0.00005434608,0.0002608803,0.0007229312,0.00002815429,0.00002693019,0.0004173797,0.00004239619,0.001069334,0.9602343,0.0004157453,0.03670803,0.00001953304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5113295,0.01679513,0.4146973,0.001015933,0.001226988,0.004710758,0.007410039,0.004983882,0.03783049],"genre_scores_gemma":[0.7066789,0.009182926,0.2246837,0.000838399,0.0002451765,0.003414835,0.008560617,0.0007754462,0.04562009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002906557,"threshold_uncertainty_score":0.009723425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423606478166952,"score_gpt":0.2658711299349949,"score_spread":0.2516350651533254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}