{"id":"W2134068760","doi":"10.1212/wnl.0000000000001240","title":"Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease","year":2015,"lang":"en","type":"letter","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; Toronto Western Hospital","funders":"Parkinson Society Canada","keywords":"Immunohistochemistry; Western blot; Biomarker; Parkinson's disease; Pathology; Biopsy; Medicine; Blot; Internal medicine; Biology; Disease; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007080643,0.0003673466,0.0003027696,0.0004334509,0.000228669,0.0004878885,0.0001615507,0.0005619282,0.0007462046],"category_scores_gemma":[0.001437581,0.0002268655,0.0001802305,0.0002092086,0.0004759555,0.0002975829,0.000197598,0.0002687438,0.0002383194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001955279,"about_ca_system_score_gemma":0.0001545708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006670426,"about_ca_topic_score_gemma":0.00145303,"domain_scores_codex":[0.9996719,0.00009468258,0.00003753699,0.00008560566,0.00006993758,0.00004035451],"domain_scores_gemma":[0.9989625,0.0003079454,0.0003012988,0.00008500679,0.0002190497,0.0001242711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00111867,0.00005539627,0.6629024,0.0001593023,0.00008995338,0.002305421,0.0001050681,0.0001912507,0.3203788,0.00004350131,0.0001021388,0.01254809],"study_design_scores_gemma":[0.00002685147,0.001235041,0.9504552,0.00006766746,0.000143825,0.01363464,0.0002376821,0.001049551,0.03216907,0.00005523462,0.0009163006,0.000008910031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.996759,0.002182666,0.0004304066,0.00005742801,0.000008576563,0.000008968742,0.00003143202,0.00001074042,0.0005108757],"genre_scores_gemma":[0.9984639,0.0004707197,0.0008124601,0.00005343764,0.0000125663,0.000004181258,0.00004665116,0.000002237723,0.0001337273],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.0007462046,"threshold_uncertainty_score":0.003744602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04303212967541684,"score_gpt":0.2954466495877702,"score_spread":0.2524145199123533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}