{"id":"W2134068760","doi":"10.1212/wnl.0000000000001240","title":"Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease","year":2015,"lang":"en","type":"letter","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; Toronto Western Hospital","funders":"Parkinson Society Canada","keywords":"Immunohistochemistry; Western blot; Biomarker; Parkinson's disease; Pathology; Biopsy; Medicine; Blot; Internal medicine; Biology; Disease; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001786545,0.0006431899,0.0009735316,0.000293124,0.0001143268,0.00003606542,0.0002717909,0.001104391,0.0007136805],"category_scores_gemma":[0.0002240622,0.0005764037,0.0005033889,0.000149619,0.00016753,0.00004688368,0.0001240542,0.001074036,0.0007555808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384934,"about_ca_system_score_gemma":0.0007234465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009520028,"about_ca_topic_score_gemma":0.00002014071,"domain_scores_codex":[0.9966188,0.0002442558,0.0004173965,0.001275025,0.0005209012,0.0009236304],"domain_scores_gemma":[0.9977755,0.0002184309,0.0002579068,0.0009266008,0.0002044971,0.0006170618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007757028,0.0004360815,0.002253833,0.0002345999,0.00038652,0.0154506,0.00001311703,3.293074e-7,0.00005626644,0.00006270085,0.9723233,0.001025603],"study_design_scores_gemma":[0.004409319,0.002634025,0.01728354,0.00002879644,0.00127871,0.0002339924,6.974939e-7,0.0002582603,0.00002605537,0.002639995,0.9708341,0.0003724515],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2234911,0.001439735,0.00006106684,0.7643217,0.002477771,0.003042284,0.0016058,0.000320162,0.003240301],"genre_scores_gemma":[0.1591905,0.0001437538,0.0001775523,0.8292922,0.003612579,0.0007782598,0.002930562,0.0002702965,0.003604247],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06497046,"threshold_uncertainty_score":0.9996687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04303212967541684,"score_gpt":0.2954466495877702,"score_spread":0.2524145199123533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}