{"id":"W2134070809","doi":"10.2337/db09-0323","title":"The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Mediator; Adipose tissue; Insulin resistance; Infiltration (HVAC); Cell biology; Macrophage; Anaphylatoxin; Receptor; Endocrinology; Chemistry; Internal medicine; Biology; Insulin; Medicine; Immunology; Immune system; Materials science; Complement system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408064,0.00009407509,0.0001307174,0.00004027693,0.0002528544,0.00002177909,0.00005906506,0.00006737535,0.00007622036],"category_scores_gemma":[0.0001697557,0.00007688167,0.00001751508,0.0001000588,0.00009644264,0.0001085934,0.00001912259,0.00006756202,0.000007779335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001459862,"about_ca_system_score_gemma":0.0000131188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007856391,"about_ca_topic_score_gemma":0.000009523386,"domain_scores_codex":[0.9993151,0.0001118589,0.0002314662,0.0001616504,0.00003417953,0.0001457508],"domain_scores_gemma":[0.9994351,0.0001994973,0.0001500468,0.0001472897,0.00004968553,0.00001836263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003084774,0.00003034843,0.009959029,0.00002466199,0.00004537191,3.088608e-8,0.0004802447,4.904637e-7,0.963414,0.0001752526,0.01130719,0.01453257],"study_design_scores_gemma":[0.0005783454,0.0001441523,0.06002632,0.00007294191,0.0000247183,2.024875e-7,0.0004167989,0.00001658537,0.913712,0.0003411745,0.02454583,0.000120924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855837,0.01309427,0.00002573122,0.0006740792,0.0000855257,0.0002400281,0.0001827367,0.0000256948,0.00008824695],"genre_scores_gemma":[0.9992362,0.0001023023,0.0000607265,0.0000723494,0.00001857183,0.00002161993,0.0001318207,0.000005698938,0.0003506797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05006729,"threshold_uncertainty_score":0.3135143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00619103998896973,"score_gpt":0.2218804243724626,"score_spread":0.2156893843834929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}