{"id":"W2134070809","doi":"10.2337/db09-0323","title":"The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation","year":2009,"lang":"en","type":"article","venue":"Diabetes","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Mediator; Adipose tissue; Insulin resistance; Infiltration (HVAC); Cell biology; Macrophage; Anaphylatoxin; Receptor; Endocrinology; Chemistry; Internal medicine; Biology; Insulin; Medicine; Immunology; Immune system; Materials science; Complement system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000349194,0.0006566406,0.0002999064,0.0002898893,0.0001828416,0.0003081691,0.0002396309,0.0003545253,0.001951803],"category_scores_gemma":[0.0001617898,0.0001394884,0.0004163365,0.0001909233,0.0003157041,0.000169917,0.0003109426,0.0005924829,0.0004474344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000306983,"about_ca_system_score_gemma":0.0001893007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003979463,"about_ca_topic_score_gemma":0.0002733524,"domain_scores_codex":[0.9998172,0.00004157528,0.00001354616,0.00004219509,0.00004740743,0.00003798574],"domain_scores_gemma":[0.999845,0.00001852097,0.00006480441,0.0000101877,0.00002483386,0.0000365709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006778457,0.00004401512,0.00159556,0.00008770731,0.00003125068,0.000190789,0.00001060622,0.00008119844,0.9927896,0.0001789808,0.0001969038,0.004115675],"study_design_scores_gemma":[0.0002697677,0.002643752,0.1255281,0.0001171278,0.000322969,0.004476375,0.0001413086,0.003386191,0.8461785,0.0007891899,0.0161026,0.00004399806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744861,0.01461723,0.006182179,0.0007161106,0.000113335,0.00005069543,0.0005573345,0.0001885456,0.00308841],"genre_scores_gemma":[0.9891384,0.004575502,0.002635684,0.0002374929,0.00005005653,0.0000467736,0.0003695528,0.00002550722,0.002920884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001951803,"threshold_uncertainty_score":0.00652945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00619103998896973,"score_gpt":0.2218804243724626,"score_spread":0.2156893843834929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}