{"id":"W2134076623","doi":"10.1002/pro.274","title":"Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Mutant; Mutation; Plasma protein binding; Binding site; Protein structure; Biophysics; Chemistry; Wild type; Dimer; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984971,0.000057367,0.00007780633,0.00005296774,0.00008806035,0.00001138715,0.00007436976,0.00003342043,0.000003545985],"category_scores_gemma":[0.0001072109,0.00004773872,0.00003043198,0.0001626836,0.0001525711,0.00001517703,0.00002884974,0.0000198877,1.004859e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007275587,"about_ca_system_score_gemma":0.00008879798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004017227,"about_ca_topic_score_gemma":0.000001977252,"domain_scores_codex":[0.9994597,0.000006124738,0.0001203811,0.0001852093,0.0001110196,0.0001175345],"domain_scores_gemma":[0.9996331,0.000002469905,0.0001071812,0.00008690784,0.000140281,0.00003005725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007448612,0.00001069738,0.0003278488,0.00001215518,0.000002528551,4.546596e-8,0.00005542851,8.515526e-7,0.9930391,0.001002156,4.869214e-7,0.005474268],"study_design_scores_gemma":[0.0002998693,0.0005184925,0.02509596,0.00001633382,0.000002872717,0.000003308774,0.00002727904,0.0002746913,0.9729648,0.0006691947,0.00006888313,0.00005836164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932407,0.00002934274,0.006115798,0.00003179395,0.00003811731,0.0004589878,0.00003098937,0.000002676634,0.00005165518],"genre_scores_gemma":[0.9987789,0.000003639605,0.001078258,0.00001639965,0.00003017805,0.00002305028,0.00001731466,0.000002684952,0.00004953794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02476811,"threshold_uncertainty_score":0.1946729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354060794125939,"score_gpt":0.2500556572637587,"score_spread":0.2365150493224993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}