{"id":"W2134076623","doi":"10.1002/pro.274","title":"Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Mutant; Mutation; Plasma protein binding; Binding site; Protein structure; Biophysics; Chemistry; Wild type; Dimer; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030377,0.0003801764,0.0002701604,0.0001444077,0.000178825,0.0002150845,0.0004010341,0.0005179891,0.000977817],"category_scores_gemma":[0.0001723698,0.0001540722,0.0003688494,0.0001296641,0.0002911615,0.0001088824,0.0002127195,0.000759845,0.0004763531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000381299,"about_ca_system_score_gemma":0.0001906722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001880629,"about_ca_topic_score_gemma":0.001399113,"domain_scores_codex":[0.9999098,0.00001293943,0.00000900669,0.00001412564,0.00003957931,0.00001453533],"domain_scores_gemma":[0.999832,0.0000233994,0.00003858593,0.00001152185,0.00002184768,0.00007257696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006329197,0.00003392418,0.0001395649,0.00001299364,0.000009779867,0.0001688254,0.00001547111,0.0001736692,0.998747,0.0001010836,0.00004834693,0.0004860684],"study_design_scores_gemma":[0.00008584719,0.0003780058,0.009225774,0.00001621556,0.00004716004,0.002279759,0.000107668,0.008490188,0.9738419,0.0001679803,0.005330623,0.00002895433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997607,0.0002979858,0.001052825,0.00007886565,0.00002423685,0.0000133781,0.0003412907,0.00003211522,0.0005523304],"genre_scores_gemma":[0.9951644,0.0002000886,0.002069192,0.00004979422,0.000006338169,0.00001683849,0.001069448,0.00005691051,0.001367001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880629,"threshold_uncertainty_score":0.003739417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354060794125939,"score_gpt":0.2500556572637587,"score_spread":0.2365150493224993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}