{"id":"W2134123270","doi":"10.1371/journal.pone.0013831","title":"Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Ontario Institute for Cancer Research","keywords":"Cancer stem cell; Tranilast; Cancer research; Aryl hydrocarbon receptor; Stem cell; Chemistry; CD44; Biology; Pharmacology; Cell; Cell biology; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001080204,0.0002750545,0.000586126,0.0001051649,0.000093114,0.00003951468,0.0001287886,0.0001752733,0.00164459],"category_scores_gemma":[0.00000736736,0.0002487595,0.0001252788,0.000329539,0.0001303069,0.00007648479,0.00005695528,0.0005761746,0.0002499291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001259772,"about_ca_system_score_gemma":0.0001672148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006735651,"about_ca_topic_score_gemma":0.0004619163,"domain_scores_codex":[0.9982073,0.00001591456,0.0003213522,0.0004761454,0.0005359554,0.0004433596],"domain_scores_gemma":[0.9987221,0.00002671579,0.0001830427,0.0005254187,0.000145649,0.0003970368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000255816,0.001664766,0.006093913,0.0003720124,0.0003041835,0.00001683292,0.0001256495,2.937949e-7,0.9639923,0.000001623766,0.02441527,0.002757339],"study_design_scores_gemma":[0.002166478,0.000143333,0.002300306,0.000703902,0.0006485357,0.00002014931,0.00009013009,0.0001076073,0.9801774,0.000003338363,0.01329446,0.0003443842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930829,0.0006956541,0.000005267904,0.002847627,0.0004825505,0.0006255377,0.0007408017,0.0001079117,0.001411683],"genre_scores_gemma":[0.9855964,0.0008061308,0.0004388229,0.001206539,0.0007632331,0.0001400746,0.0000869545,0.00008597444,0.01087592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01618508,"threshold_uncertainty_score":0.9999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851227796590425,"score_gpt":0.2265117827121954,"score_spread":0.2079995047462911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}