{"id":"W2134156907","doi":"10.1242/jcs.150961","title":"Proteasome dysfunction induces muscle growth defects and protein aggregation","year":2014,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center of Neurology and Psychiatry; York University","keywords":"Autophagy; Biology; Proteasome; Cell biology; Lysosome; Myocyte; Ubiquitin; Organelle; Sarcomere; Autophagosome; Protein degradation; Biochemistry; Gene; Apoptosis; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269686,0.0006940759,0.0003536277,0.0004061839,0.0002041476,0.0001960409,0.0001503708,0.0004294383,0.001279278],"category_scores_gemma":[0.0001019589,0.0001817173,0.0003634631,0.0001842808,0.0003258512,0.0001259991,0.0003039064,0.0005512609,0.0003468108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000346022,"about_ca_system_score_gemma":0.0002484624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000563191,"about_ca_topic_score_gemma":0.0009093895,"domain_scores_codex":[0.999855,0.00001834536,0.00001789764,0.00003794608,0.00003816726,0.00003264836],"domain_scores_gemma":[0.9998626,0.00001560075,0.00004918312,0.00001458472,0.000009563149,0.0000485397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001567613,0.00003120585,0.0003540599,0.00003415001,0.00001257513,0.0004004952,0.000009139161,0.0000511964,0.9979704,0.00005250419,0.00006339795,0.000864046],"study_design_scores_gemma":[0.00005752352,0.0008917336,0.02133522,0.00001867241,0.00005556061,0.003349363,0.0000452953,0.001157559,0.9704714,0.0001558582,0.002452759,0.000009115459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958106,0.001195352,0.001184355,0.00006542666,0.00003646508,0.00001864441,0.0003797685,0.0001748232,0.001134642],"genre_scores_gemma":[0.9964513,0.0006507174,0.0006960527,0.00003485259,0.000008184644,0.00002248343,0.0003929852,0.00002751409,0.001716004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279278,"threshold_uncertainty_score":0.004279554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007901086918855953,"score_gpt":0.2351667688518696,"score_spread":0.2272656819330136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}