{"id":"W2134176045","doi":"10.1002/anie.200603284","title":"Inhibition of siRNA Binding to a p19 Viral Suppressor of RNA Silencing by Cysteine Alkylation","year":2007,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Steacie Institute for Molecular Sciences; University of Ottawa","funders":"","keywords":"Small interfering RNA; RNA; Trans-acting siRNA; Gene silencing; RNA silencing; Cysteine; RNA-induced silencing complex; RNA interference; Chemistry; Suppressor; Binding site; Molecular biology; Cell biology; Biochemistry; Biology; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197488,0.0001073685,0.0001155571,0.0001209297,0.00002451586,0.000009782601,0.0001161135,0.0001135909,0.000053891],"category_scores_gemma":[0.000108805,0.0001145639,0.00008119734,0.00008248175,0.00003490201,0.00002531569,0.00005787397,0.00005588475,0.000006310069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004081513,"about_ca_system_score_gemma":0.00002069348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005794928,"about_ca_topic_score_gemma":0.00001708877,"domain_scores_codex":[0.9990406,0.000009728871,0.0003525042,0.0002090006,0.0002540188,0.0001341494],"domain_scores_gemma":[0.9992983,0.00001946613,0.0002044554,0.0001197985,0.0003085426,0.00004948456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001997855,0.00006036869,0.0002196966,0.00001978443,0.00004264717,0.000001260813,0.0001170163,0.00003873905,0.9907714,0.00002316677,0.007816105,0.0006900646],"study_design_scores_gemma":[0.0004098441,0.0002845897,0.0003132115,0.0001007715,0.00001244462,0.000004741662,0.0001335132,0.00002197878,0.9976759,0.00005753225,0.0008744812,0.000111002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779299,0.00007189093,0.01884716,0.000114665,0.0004368697,0.0001060433,0.0002159905,0.000007495477,0.002269997],"genre_scores_gemma":[0.9969712,0.000038529,0.000311466,0.0001164315,0.0006103325,0.000009098292,0.001618719,0.00001159939,0.0003125692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01904137,"threshold_uncertainty_score":0.4671778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009335824889896809,"score_gpt":0.2574944022996407,"score_spread":0.2481585774097439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}