{"id":"W2134176045","doi":"10.1002/anie.200603284","title":"Inhibition of siRNA Binding to a p19 Viral Suppressor of RNA Silencing by Cysteine Alkylation","year":2007,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Steacie Institute for Molecular Sciences; University of Ottawa","funders":"","keywords":"Small interfering RNA; RNA; Trans-acting siRNA; Gene silencing; RNA silencing; Cysteine; RNA-induced silencing complex; RNA interference; Chemistry; Suppressor; Binding site; Molecular biology; Cell biology; Biochemistry; Biology; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002434224,0.0004123305,0.0003225804,0.0001899257,0.0001883492,0.0002486418,0.0004238421,0.0003634544,0.001014637],"category_scores_gemma":[0.0001754521,0.0001413355,0.0002727063,0.0001417293,0.0002227302,0.0001366312,0.0002030342,0.0004052457,0.0003832309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004057785,"about_ca_system_score_gemma":0.0001962721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005540279,"about_ca_topic_score_gemma":0.0009496767,"domain_scores_codex":[0.9997769,0.00004029963,0.00002462844,0.00005324114,0.00005864305,0.00004620353],"domain_scores_gemma":[0.9998975,0.00003285709,0.00002379052,0.00001422564,0.00001539769,0.00001616671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005140178,0.00001722733,0.0000322623,0.00001689842,0.00000306109,0.00001784822,0.00000501145,0.0000306932,0.9990589,0.00005468061,0.00001956964,0.0006924404],"study_design_scores_gemma":[0.000006344798,0.000093074,0.0002135548,5.253067e-7,0.000002676369,0.00002560651,0.000001384152,0.0002023193,0.998868,0.000005557795,0.0005801228,9.566249e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882783,0.001629891,0.00661083,0.00009596138,0.00004123427,0.0001000811,0.0002595112,0.0001546431,0.002829653],"genre_scores_gemma":[0.9895873,0.0009520148,0.005474939,0.00005027544,0.00001318731,0.00008326367,0.0004979398,0.00003626312,0.003304806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001014637,"threshold_uncertainty_score":0.003394365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009335824889896809,"score_gpt":0.2574944022996407,"score_spread":0.2481585774097439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}