{"id":"W2134182367","doi":"10.1128/jb.00590-09","title":"An A257V Mutation in the <i>Bacillus subtilis</i> Response Regulator Spo0A Prevents Regulated Expression of Promoters with Low-Consensus Binding Sites","year":2009,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Promoter; Biology; Transcription (linguistics); Transcription factor; Mutant; Bacillus subtilis; Response element; DNA-binding protein; Consensus sequence; Binding site; Molecular biology; Cell biology; Genetics; Gene; Gene expression; Peptide sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698954,0.000614488,0.000281728,0.0002757548,0.0002446308,0.0004061042,0.0006688113,0.0004853135,0.00137263],"category_scores_gemma":[0.0001900714,0.0003247918,0.0004911085,0.0001696908,0.0005540636,0.0001243544,0.0003232173,0.0006075757,0.0009701129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003986444,"about_ca_system_score_gemma":0.0003793582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517716,"about_ca_topic_score_gemma":0.001943826,"domain_scores_codex":[0.9997017,0.00005405456,0.00004888903,0.00005087248,0.0001005237,0.00004387042],"domain_scores_gemma":[0.9996541,0.00009382849,0.0001019003,0.00004056422,0.00001905378,0.00009065351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006685374,0.00005873638,0.0001688078,0.00002792766,0.00001070212,0.0001158045,0.00001304381,0.00009098813,0.998571,0.0001893504,0.0000451571,0.0006414847],"study_design_scores_gemma":[0.00003038574,0.0003723766,0.003171014,0.00001979842,0.00002865301,0.0004133588,0.0000469527,0.001420975,0.991722,0.00007890523,0.002678079,0.00001756587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949874,0.0004264079,0.002497788,0.00006819073,0.00005561659,0.00005067181,0.0004735205,0.0001558514,0.001284564],"genre_scores_gemma":[0.9941591,0.0002727495,0.002466858,0.00008097159,0.00001274446,0.00005312004,0.0008328322,0.00009208419,0.002029573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517716,"threshold_uncertainty_score":0.004591942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006753868291746717,"score_gpt":0.2352225151916744,"score_spread":0.2284686468999277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}