{"id":"W2134185564","doi":"10.1074/jbc.m200729200","title":"Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Servier; Ligue Contre le Cancer; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"Receptor; Ligand (biochemistry); Biophysics; Förster resonance energy transfer; Chemistry; G protein-coupled receptor; Melatonin receptor; Agonist; Bioluminescence; HEK 293 cells; Population; Biochemistry; Stereochemistry; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003478225,0.0002991571,0.0003070754,0.00016174,0.0001429805,0.0003137959,0.0002818467,0.0004120364,0.0008153695],"category_scores_gemma":[0.0003532964,0.0001312589,0.0002170451,0.0002007282,0.0002045412,0.0003315858,0.0002220447,0.0006247039,0.0004078016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301031,"about_ca_system_score_gemma":0.00008444773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00019974,"about_ca_topic_score_gemma":0.000231328,"domain_scores_codex":[0.9997464,0.00007118977,0.00001655113,0.00007406392,0.00005689682,0.00003493144],"domain_scores_gemma":[0.9998651,0.00005392118,0.00003282179,0.00001793257,0.00001842495,0.00001186368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003112217,0.000005919194,0.00005459602,0.00001894286,0.000002045414,0.00001297781,0.00001425767,0.00002641769,0.9994779,0.00002979864,0.000009684411,0.0003163902],"study_design_scores_gemma":[0.00001007695,0.000164129,0.002550503,0.000003810586,0.000007992897,0.00009978071,0.00004459334,0.001708962,0.9947973,0.00005748627,0.0005487877,0.000006589831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729587,0.001270128,0.02403148,0.00009467372,0.00002212451,0.0000411711,0.0003533517,0.000137901,0.001090382],"genre_scores_gemma":[0.9816028,0.001357007,0.01397592,0.0001112289,0.00001554901,0.0001644769,0.0004602639,0.00002809524,0.002284669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008153695,"threshold_uncertainty_score":0.002727628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299813144910039,"score_gpt":0.2278587978982478,"score_spread":0.1978774834072439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}