{"id":"W2134193340","doi":"10.1016/j.ajpath.2011.11.030","title":"Integrative Molecular Profiling Reveals Asparagine Synthetase Is a Target in Castration-Resistant Prostate Cancer","year":2012,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Université de Montréal","funders":"National Cancer Institute","keywords":"Prostate cancer; Asparagine; Biology; Profiling (computer programming); Prostate; Cancer research; Computational biology; Cancer; Bioinformatics; Oncology; Medicine; Enzyme; Genetics; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005571987,0.0001530078,0.0005407339,0.0002700423,0.00002914982,0.000007945905,0.0000760935,0.00003723422,0.00009822757],"category_scores_gemma":[0.0001208509,0.0001005559,0.00009868339,0.0003661209,0.0002442999,0.0001279753,0.00002035664,0.000392583,0.000006209386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202348,"about_ca_system_score_gemma":0.0003603876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007529432,"about_ca_topic_score_gemma":0.000005987179,"domain_scores_codex":[0.9985332,0.0002239174,0.0004412965,0.000144063,0.0002390235,0.0004185284],"domain_scores_gemma":[0.9989639,0.00006347324,0.000361631,0.000133935,0.000259161,0.0002179206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002911875,0.0005439857,0.281045,0.00006715365,0.0002732842,0.006652151,0.007764995,0.0000317646,0.6874701,0.0002333495,0.0003666042,0.01263977],"study_design_scores_gemma":[0.01116054,0.0132011,0.1870081,0.00171271,0.0006635112,0.008178337,0.01899379,0.0001567062,0.7544996,0.001367883,0.00223467,0.0008230979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905146,0.005563283,0.0001588478,0.00301803,0.00009971754,0.0003097101,0.00004294786,0.000005471307,0.0002874388],"genre_scores_gemma":[0.9925162,0.0005597468,0.006035932,0.0005087728,0.0001077334,0.00004257509,0.000009094639,0.00001877846,0.0002011796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09403696,"threshold_uncertainty_score":0.4100549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912535622994244,"score_gpt":0.3541167269203728,"score_spread":0.3349913706904304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}