{"id":"W2134194869","doi":"10.1016/j.jaci.2013.01.052","title":"Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis","year":2013,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"NHLBI Division of Intramural Research; Sunovion; Canadian Institutes of Health Research; Pfizer Canada; Astellas Pharma; CSL Behring; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Pfizer; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"STAT1; Biology; STAT protein; Dimorphic fungus; Signal transduction; Cancer research; STAT3; Immunology; Cell biology; Genetics; Yeast","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152075,0.00009223878,0.000460897,0.0001050989,0.00007687806,0.000006205991,0.00001774193,0.0001496075,0.00008451653],"category_scores_gemma":[0.0001142713,0.00006892287,0.00008259079,0.00006864941,0.0004766586,0.0001301659,0.00001080203,0.0002599298,2.392269e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001163747,"about_ca_system_score_gemma":0.00003520732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005838958,"about_ca_topic_score_gemma":0.0000155874,"domain_scores_codex":[0.9990298,0.00008772597,0.000622727,0.0001085112,0.0000649335,0.00008636115],"domain_scores_gemma":[0.9989418,0.000439826,0.0002593163,0.0000499513,0.0002382657,0.00007083378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005198037,0.001494961,0.08723254,0.0002293357,0.007531109,0.00001433113,0.003210859,0.00000562387,0.7573746,0.0009162404,0.0006991642,0.1360932],"study_design_scores_gemma":[0.003446695,0.005654607,0.9818836,0.0001797535,0.0005907188,0.0002596452,0.001613689,0.0001023675,0.004457467,0.0005692194,0.001148164,0.00009404321],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922879,0.005742817,0.0004139064,0.00123321,0.0001484142,0.00009070237,0.000003237508,0.000003685928,0.00007617031],"genre_scores_gemma":[0.9832983,0.01624921,0.0002837376,0.00004864407,0.00002858555,0.000003239763,0.000001689253,0.000005792167,0.00008079088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8946511,"threshold_uncertainty_score":0.2810593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02057942264028889,"score_gpt":0.2942195905614503,"score_spread":0.2736401679211614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}