{"id":"W2134206147","doi":"10.1016/j.febslet.2006.06.008","title":"Lipid imbalance in the neurological disorder, Niemann‐Pick C disease","year":2006,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"NPC1; Endosome; Monoacylglycerol lipase; Niemann–Pick disease; Ganglioside; Cholesterol; Lysosome; Niemann–Pick disease, type C; Mutation; Biology; Cell biology; Chemistry; Biochemistry; Neuroscience; Gene; Endocannabinoid system; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595769,0.0007429213,0.001432972,0.002041319,0.0003546251,0.0006512176,0.0005349274,0.0009539829,0.001912687],"category_scores_gemma":[0.0003380352,0.0001675238,0.0002622491,0.002109356,0.0003624776,0.0008249049,0.0003940975,0.000721239,0.002589219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004906413,"about_ca_system_score_gemma":0.000658533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009748501,"about_ca_topic_score_gemma":0.001512039,"domain_scores_codex":[0.9998997,0.00001700393,0.00001740902,0.00001819685,0.00003788324,0.000009690614],"domain_scores_gemma":[0.9999121,0.0000243443,0.00001512079,0.000003330028,0.00002820844,0.00001684602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001297858,0.00008398885,0.0007076756,0.009722448,0.0001061231,0.002228136,0.00009911595,0.0002982494,0.004270012,0.003073541,0.04711235,0.9321684],"study_design_scores_gemma":[0.00003261721,0.0001050026,0.002990546,0.00181643,0.0001459008,0.01561236,0.0001329983,0.0000857202,0.0009183049,0.002107129,0.9760295,0.00002349468],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003481136,0.9974251,0.000158384,0.00023308,0.0002533327,0.000004859162,0.00001511555,0.0000115849,0.001550483],"genre_scores_gemma":[0.002116388,0.9959266,0.0003509923,0.0002090359,0.0002429023,0.000006379466,0.000034379,0.000001540347,0.00111176],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002041319,"threshold_uncertainty_score":0.006398559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04041470909869462,"score_gpt":0.3360462541096106,"score_spread":0.295631545010916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}