{"id":"W2134206147","doi":"10.1016/j.febslet.2006.06.008","title":"Lipid imbalance in the neurological disorder, Niemann‐Pick C disease","year":2006,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"NPC1; Endosome; Monoacylglycerol lipase; Niemann–Pick disease; Ganglioside; Cholesterol; Lysosome; Niemann–Pick disease, type C; Mutation; Biology; Cell biology; Chemistry; Biochemistry; Neuroscience; Gene; Endocannabinoid system; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003812258,0.0005459884,0.00141558,0.0002624422,0.0001012875,0.00007745149,0.0008322365,0.0002419312,0.0001131822],"category_scores_gemma":[0.0003420579,0.000320874,0.0006977822,0.0007911922,0.0002511454,0.00006262769,0.0001686427,0.00154758,0.0003609507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001164193,"about_ca_system_score_gemma":0.000178514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000123047,"about_ca_topic_score_gemma":0.00003980922,"domain_scores_codex":[0.9963036,0.0006487044,0.0006147128,0.0007771488,0.0008632711,0.0007925735],"domain_scores_gemma":[0.9982324,0.0003760931,0.0001658987,0.001000935,0.00002793922,0.0001967009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002497122,0.001464255,0.03248451,0.02704429,0.0001550428,0.009505381,0.0001138713,0.00001772544,0.000001516426,0.0001029107,0.2071133,0.7217475],"study_design_scores_gemma":[0.0005758516,0.0001028987,0.01229193,0.001567641,0.0002760061,0.00008685321,0.000005516997,0.00001797495,1.096532e-8,0.00001068167,0.9847661,0.000298516],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002029609,0.9802101,0.00002468306,0.01448771,0.0002048926,0.002214839,0.00004017271,0.00007438508,0.0007135864],"genre_scores_gemma":[0.0003914925,0.9872031,0.00002912874,0.009992047,0.0007772422,0.0005658602,0.0004509868,0.00008716668,0.0005029253],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7776528,"threshold_uncertainty_score":0.9999244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04041470909869462,"score_gpt":0.3360462541096106,"score_spread":0.295631545010916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}