{"id":"W2134213199","doi":"10.1161/circresaha.109.209189","title":"TIMP2 Deficiency Accelerates Adverse Post–Myocardial Infarction Remodeling Because of Enhanced MT1-MMP Activity Despite Lack of MMP2 Activation","year":2010,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Matrix metalloproteinase; MMP2; Myocardial infarction; Extracellular matrix; Collagenase; Tissue inhibitor of metalloproteinase; Ventricular remodeling; MMP9; Inflammation; Internal medicine; MMP1; Chemistry; Medicine; Endocrinology; Cell biology; Cardiology; Biology; Downregulation and upregulation; Biochemistry; Enzyme; Gene expression; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601148,0.0001438621,0.0003742909,0.0005793102,0.0001876201,0.00002508943,0.0001002421,0.0002627845,0.0001283645],"category_scores_gemma":[0.001022688,0.0001359551,0.0002326675,0.0008407592,0.0001721754,0.0004119893,0.00007552665,0.0006927979,0.00001446122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201068,"about_ca_system_score_gemma":0.0003749627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004914178,"about_ca_topic_score_gemma":0.00002336807,"domain_scores_codex":[0.9976279,0.0001661675,0.0004650891,0.0003763093,0.001024553,0.0003400116],"domain_scores_gemma":[0.9967452,0.0002601914,0.0002059057,0.0004812705,0.00218404,0.0001234292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003975719,0.0001382988,0.01255564,0.0001601,0.00003770264,2.448571e-7,0.0005091394,0.01258918,0.9586631,0.0001093331,0.00001221102,0.01482745],"study_design_scores_gemma":[0.0009688776,0.0001595199,0.5751177,0.0001522765,0.0000445957,0.000006006988,0.0002059575,0.05639891,0.3666168,0.0001677023,0.00003209962,0.0001295372],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993118,0.00002878483,0.003744706,0.0002571662,0.0001985977,0.0006775331,0.000009724509,0.0000363973,0.001929087],"genre_scores_gemma":[0.9989547,0.00004238906,0.0006190024,0.00002027014,0.0002143646,0.00001583765,0.00005575148,0.00002938736,0.00004836874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5920463,"threshold_uncertainty_score":0.5544087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1207752671687645,"score_gpt":0.4086699159887507,"score_spread":0.2878946488199862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}