{"id":"W2134218993","doi":"10.1093/protein/gzs020","title":"Engineered regulation of lysozyme by the SH3-CB1 binding interaction","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Lysozyme; SH3 domain; Fusion protein; Chemistry; Peptide; Adapter molecule crk; Steric effects; Plasma protein binding; Binding domain; Biochemistry; Computational biology; Binding site; Biophysics; Cell biology; Biology; Stereochemistry; Signal transducing adaptor protein; Signal transduction; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094223,0.00009604177,0.00007181118,0.00004230166,0.00004836212,0.00001268628,0.00004123704,0.00009382293,0.000003501939],"category_scores_gemma":[0.00005234728,0.0000791368,0.00002500378,0.0001020668,0.00001209886,0.00001453678,0.00001468398,0.00007988119,6.387494e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001553438,"about_ca_system_score_gemma":0.000007523827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009924162,"about_ca_topic_score_gemma":5.3738e-7,"domain_scores_codex":[0.999537,0.00003084771,0.0001204281,0.0001039346,0.00006634076,0.0001414825],"domain_scores_gemma":[0.9998041,0.0000107588,0.00005242602,0.00007000615,0.00002993352,0.00003276845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003425037,0.000009114944,0.00008426086,0.00001970091,0.00002185815,1.364828e-8,0.00003526314,0.004542754,0.992889,0.0001819518,0.00009498395,0.00208689],"study_design_scores_gemma":[0.0001503079,0.0001017482,0.0006990219,0.00001492092,0.0000128224,0.00001951477,0.000008552076,0.03497764,0.9620056,0.00002891839,0.001874554,0.0001063935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4429138,0.0005080068,0.5562119,0.0000179194,0.00006873664,0.0002454946,0.000001279037,0.0000175901,0.0000152698],"genre_scores_gemma":[0.993407,0.00002350904,0.006207957,0.00000630015,0.0001377851,0.00004648153,0.00002374099,0.00001509868,0.0001321142],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5504932,"threshold_uncertainty_score":0.3227105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006076952549519102,"score_gpt":0.2006322025514311,"score_spread":0.194555250001912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}