{"id":"W2134218993","doi":"10.1093/protein/gzs020","title":"Engineered regulation of lysozyme by the SH3-CB1 binding interaction","year":2012,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Lysozyme; SH3 domain; Fusion protein; Chemistry; Peptide; Adapter molecule crk; Steric effects; Plasma protein binding; Binding domain; Biochemistry; Computational biology; Binding site; Biophysics; Cell biology; Biology; Stereochemistry; Signal transducing adaptor protein; Signal transduction; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710446,0.0002459945,0.000185369,0.000119003,0.0001563634,0.0002787173,0.0003250349,0.0002250946,0.0006457536],"category_scores_gemma":[0.0002118217,0.0001106682,0.0001717092,0.0001275879,0.0002700517,0.0001564152,0.0001822569,0.0004402318,0.0001869415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007569023,"about_ca_system_score_gemma":0.0003950866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263637,"about_ca_topic_score_gemma":0.001914631,"domain_scores_codex":[0.9999268,0.00001049782,0.000006996418,0.00001544639,0.00002268816,0.00001760156],"domain_scores_gemma":[0.9999117,0.00002172925,0.0000301778,0.000007494646,0.00001156376,0.00001738481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005037246,0.0000161606,0.0001517591,0.00001304063,0.000002749242,0.0000280227,0.000008093683,0.0005788273,0.9983694,0.0001708961,0.00001511151,0.0005956227],"study_design_scores_gemma":[0.00001602349,0.00006160055,0.0004395785,0.000002009818,0.000006395271,0.00005834303,0.00000746528,0.003745967,0.9947607,0.00004542976,0.0008518709,0.000004715914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913875,0.0002137502,0.007450727,0.00005401189,0.00001192413,0.00002633241,0.00009768368,0.00006824019,0.0006897134],"genre_scores_gemma":[0.9913225,0.0001196476,0.007510741,0.0000385401,0.000002573161,0.00002552149,0.0001285406,0.00002321769,0.0008286506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263637,"threshold_uncertainty_score":0.005491734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006076952549519102,"score_gpt":0.2006322025514311,"score_spread":0.194555250001912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}