{"id":"W2134234533","doi":"10.1161/circulationaha.106.621433","title":"Both Hepatic and Extrahepatic ABCA1 Have Discrete and Essential Functions in the Maintenance of Plasma High-Density Lipoprotein Cholesterol Levels In Vivo","year":2006,"lang":"en","type":"article","venue":"Circulation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Killam Trusts; National Institutes of Health; Michael Smith Health Research BC; Heart and Stroke Foundation of Canada","keywords":"ABCA1; In vivo; Cholesterol; Reverse cholesterol transport; Endocrinology; Internal medicine; High-density lipoprotein; Apolipoprotein B; Phospholipid; Lipoprotein; Medicine; Apolipoprotein E; Biology; Biochemistry; Transporter; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002612013,0.0003644681,0.0002757217,0.0002856544,0.0001866684,0.0006124814,0.0001987786,0.0003331082,0.001559118],"category_scores_gemma":[0.0002029306,0.0001666609,0.0002099223,0.0002160108,0.0003720224,0.0003217621,0.0002867991,0.0004932762,0.0006487435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743937,"about_ca_system_score_gemma":0.0002508996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005555099,"about_ca_topic_score_gemma":0.0006790183,"domain_scores_codex":[0.9998355,0.00002258147,0.00002073736,0.00003384905,0.00004865777,0.00003865093],"domain_scores_gemma":[0.9996945,0.000050695,0.00008301069,0.0000484191,0.00004284217,0.0000806237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004160332,0.00003229216,0.001972859,0.0001005672,0.000009216678,0.000103381,0.00001863484,0.00005221469,0.9930196,0.0003632328,0.00006929829,0.003842587],"study_design_scores_gemma":[0.00008125657,0.000303522,0.0281718,0.00001972256,0.00007065891,0.001699357,0.00008662869,0.0008646015,0.9636851,0.0002734619,0.004730242,0.00001366245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805385,0.006841841,0.008856226,0.0004377085,0.00004429616,0.00003686436,0.0004809479,0.0001578799,0.002605769],"genre_scores_gemma":[0.992734,0.001829706,0.00280165,0.00006580206,0.00001898427,0.00004111125,0.0003726078,0.0000339951,0.002102171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559118,"threshold_uncertainty_score":0.005215764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106329586180742,"score_gpt":0.2312377855211645,"score_spread":0.2206048269030903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}