{"id":"W2134234533","doi":"10.1161/circulationaha.106.621433","title":"Both Hepatic and Extrahepatic ABCA1 Have Discrete and Essential Functions in the Maintenance of Plasma High-Density Lipoprotein Cholesterol Levels In Vivo","year":2006,"lang":"en","type":"article","venue":"Circulation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Killam Trusts; National Institutes of Health; Michael Smith Health Research BC; Heart and Stroke Foundation of Canada","keywords":"ABCA1; In vivo; Cholesterol; Reverse cholesterol transport; Endocrinology; Internal medicine; High-density lipoprotein; Apolipoprotein B; Phospholipid; Lipoprotein; Medicine; Apolipoprotein E; Biology; Biochemistry; Transporter; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002747511,0.0001152727,0.0002517515,0.0001261821,0.00004292332,0.0000222836,0.00003356808,0.00007290344,0.000008465707],"category_scores_gemma":[0.00004473072,0.00008785593,0.0000297716,0.0001424469,0.00009766886,0.0001299211,0.00001677582,0.0001424572,5.463587e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002795381,"about_ca_system_score_gemma":0.00001662492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004362981,"about_ca_topic_score_gemma":0.004802656,"domain_scores_codex":[0.9990455,0.00008410014,0.0003232951,0.0002152047,0.0001829095,0.0001489892],"domain_scores_gemma":[0.999587,0.00005454251,0.0001047948,0.0001919964,0.00002994114,0.00003170788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001220082,0.0001774598,0.9122308,0.0002564221,0.00001558758,0.00001566857,0.001740354,0.0003656366,0.07376399,0.0005888133,0.00002541173,0.01069787],"study_design_scores_gemma":[0.002166785,0.00002713216,0.9880252,0.0001766843,0.0000562779,0.00004209865,0.0001464732,0.007251432,0.001395626,0.0005916686,0.00004080866,0.00007980127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969773,0.00009507121,0.001740004,0.0004080429,0.00007909357,0.000550477,0.00001047776,0.00001043834,0.0001290961],"genre_scores_gemma":[0.999559,0.000009774582,0.0000944398,0.00006975773,0.0001388439,0.00002717812,0.00001448814,0.00001051763,0.00007604017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07579443,"threshold_uncertainty_score":0.6595552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106329586180742,"score_gpt":0.2312377855211645,"score_spread":0.2206048269030903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}