{"id":"W2134237683","doi":"10.1093/cvr/cvm039","title":"NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition","year":2007,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medical Council of Canada; Western University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mitochondrial permeability transition pore; Mitochondrion; Cardioprotection; Ischemia; Cytochrome c oxidase; Mitochondrial membrane transport protein; Cytochrome c; Chemistry; Apoptosis-inducing factor; Molecular biology; Biology; Biochemistry; Apoptosis; Internal medicine; Medicine; Programmed cell death; Inner mitochondrial membrane; Caspase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234026,0.0005529607,0.0007587948,0.000156239,0.0001393995,0.0003160609,0.0002553875,0.0003559171,0.002060117],"category_scores_gemma":[0.0001991178,0.0001586185,0.0003952625,0.0001053094,0.0002788385,0.0004556674,0.0002511094,0.0008538007,0.0003379704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677357,"about_ca_system_score_gemma":0.0001274716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009099396,"about_ca_topic_score_gemma":0.0001879698,"domain_scores_codex":[0.9998944,0.00001355612,0.00001204794,0.00002449014,0.00001944163,0.00003606935],"domain_scores_gemma":[0.9998757,0.00001661671,0.00006144881,0.00001454309,0.0000107176,0.00002096962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007098991,0.00006641397,0.0001840997,0.0001452302,0.00002486435,0.00005066366,0.00001354697,0.00003340326,0.9956541,0.00004169618,0.00005764783,0.003018411],"study_design_scores_gemma":[0.0001293437,0.002472747,0.02063863,0.0000248663,0.00008649023,0.0005446376,0.00002420665,0.0004787903,0.9737566,0.00009424047,0.001742826,0.000006708533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98138,0.01358343,0.003066778,0.0002313538,0.0001099993,0.00005747532,0.0003237021,0.0001856947,0.001061563],"genre_scores_gemma":[0.9924133,0.004568217,0.001352067,0.00008497671,0.00005719018,0.00004629423,0.0004833677,0.00002200034,0.0009726874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002060117,"threshold_uncertainty_score":0.006891787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03602757864207477,"score_gpt":0.2989381145111956,"score_spread":0.2629105358691208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}