{"id":"W2134295150","doi":"10.1128/mcb.22.15.5479-5491.2002","title":"TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Manitoba Health Research Council","keywords":"Pleckstrin homology domain; Biology; Phosphatidylinositol; Cell biology; B-cell receptor; breakpoint cluster region; Signal transduction; Phosphoinositide 3-kinase; Cell membrane; PI3K/AKT/mTOR pathway; C2 domain; Molecular biology; Receptor; B cell; Membrane; Biochemistry; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003685868,0.0003889864,0.0006911155,0.0001517013,0.0002087069,0.00001628933,0.0003115177,0.0005948549,0.0004203222],"category_scores_gemma":[0.00003606327,0.0002975004,0.0001247933,0.0002121952,0.0006760832,0.00003734548,0.0001817699,0.000431596,0.00004898604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000254825,"about_ca_system_score_gemma":0.00002322832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001577825,"about_ca_topic_score_gemma":0.000009287429,"domain_scores_codex":[0.9973507,0.0007084862,0.0006185776,0.0006310791,0.00004545192,0.0006457248],"domain_scores_gemma":[0.998981,0.0001946476,0.000323085,0.0003863527,0.00006445702,0.00005046428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001946104,0.0004123754,0.0007997351,0.00006739194,0.000170318,0.00004522111,0.0005958758,0.00000578485,0.9944205,0.0002345919,0.0009117261,0.00214189],"study_design_scores_gemma":[0.00343997,0.0004452476,0.00001169502,0.0000281173,0.00006680888,0.00002093105,0.001018099,0.00005160728,0.9515833,0.00007025989,0.04294795,0.0003160593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9127071,0.0851601,0.0001629532,0.0004559403,0.0003264611,0.0007741725,0.00007051747,0.00003091868,0.0003118097],"genre_scores_gemma":[0.994974,0.00277525,0.00010034,0.0001858669,0.000014965,0.00007360823,0.0002060438,0.00003126733,0.001638681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08238485,"threshold_uncertainty_score":0.9999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235791631011791,"score_gpt":0.2053865914878943,"score_spread":0.1930286751777764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}