{"id":"W2134295150","doi":"10.1128/mcb.22.15.5479-5491.2002","title":"TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Manitoba Health Research Council","keywords":"Pleckstrin homology domain; Biology; Phosphatidylinositol; Cell biology; B-cell receptor; breakpoint cluster region; Signal transduction; Phosphoinositide 3-kinase; Cell membrane; PI3K/AKT/mTOR pathway; C2 domain; Molecular biology; Receptor; B cell; Membrane; Biochemistry; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575989,0.0005021962,0.0002643727,0.0002645956,0.0002556052,0.0004414469,0.0003071226,0.0005136839,0.0008280571],"category_scores_gemma":[0.0001619819,0.0001627164,0.0001979946,0.0002238861,0.0001986651,0.000394403,0.0003973767,0.0007172567,0.0005593797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003572523,"about_ca_system_score_gemma":0.0001978353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002641081,"about_ca_topic_score_gemma":0.0003199415,"domain_scores_codex":[0.9998323,0.00001921976,0.00001115222,0.00003642348,0.00005849163,0.00004238427],"domain_scores_gemma":[0.9998952,0.00001370224,0.00002657059,0.000008512824,0.00001450264,0.00004149241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005064535,0.00000951304,0.0001645867,0.00002865242,0.000002082063,0.0001042218,0.00001337518,0.00002164599,0.9987249,0.00005279227,0.00003392417,0.0007937917],"study_design_scores_gemma":[0.00002270976,0.0001434784,0.009140529,0.000006604695,0.00001556958,0.002115859,0.0000426855,0.001438156,0.9819094,0.0001081941,0.005046185,0.00001067479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874976,0.003913363,0.006407279,0.0002902704,0.0000322567,0.00005248682,0.0006855891,0.000109947,0.001011249],"genre_scores_gemma":[0.9856575,0.002225626,0.00729725,0.0001273467,0.00005209234,0.0001198184,0.00180103,0.00003860037,0.002680788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008280571,"threshold_uncertainty_score":0.002770126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235791631011791,"score_gpt":0.2053865914878943,"score_spread":0.1930286751777764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}