{"id":"W2134303620","doi":"10.1091/mbc.e10-05-0424","title":"Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα","year":2010,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences","keywords":"Biology; Phosphatidylinositol; Cell biology; Golgi apparatus; Sphingomyelin; Kinase; Pleckstrin homology domain; Oxysterol; Biochemistry; Sphingolipid; Protein kinase A; Plasma protein binding; Membrane; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004870889,0.0001661343,0.0001972986,0.0000589624,0.00006163774,0.000007875675,0.0005313418,0.0002944249,0.00001385314],"category_scores_gemma":[0.00009563963,0.0001114387,0.0001676579,0.0001316563,0.0001957663,0.000004461607,0.0000749122,0.0002247979,0.000002030056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007202663,"about_ca_system_score_gemma":0.00004935073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000924316,"about_ca_topic_score_gemma":0.00006273325,"domain_scores_codex":[0.9988052,0.0002023371,0.0003553653,0.0002886231,0.0001409191,0.0002075049],"domain_scores_gemma":[0.9990269,0.00002801708,0.0002681601,0.0005941834,0.00005686122,0.0000259055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009896735,0.0001072695,0.003941835,0.00005123943,0.00002326277,0.000002270463,0.0001012781,0.00003193126,0.9951186,0.0002048336,0.000006097231,0.0003124687],"study_design_scores_gemma":[0.0003462131,0.0001098281,0.000973409,0.00003424758,0.00002972746,0.000003552326,0.0000793935,0.00002887712,0.9971858,0.0001335673,0.0009564232,0.0001189106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959909,0.0002325327,0.002458904,0.0002530783,0.0001388902,0.00055322,0.00001711163,0.00000435366,0.0003509958],"genre_scores_gemma":[0.9992396,0.0000191831,0.0003097938,0.00005773439,0.00004480202,0.00005536707,0.0001658911,0.00001612492,0.00009147089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003248719,"threshold_uncertainty_score":0.4544338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006462591212724671,"score_gpt":0.2233325679225588,"score_spread":0.2168699767098341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}