{"id":"W2134318552","doi":"10.1158/1078-0432.ccr-07-4575","title":"Phase II, Open-Label Study Evaluating the Activity of Imatinib in Treating Life-Threatening Malignancies Known to Be Associated with Imatinib-Sensitive Tyrosine Kinases","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Imatinib; Medicine; Systemic mastocytosis; Tyrosine kinase; Dermatofibrosarcoma protuberans; Imatinib mesylate; Tyrosine-kinase inhibitor; PDGFRA; Malignancy; Cancer research; Internal medicine; GiST; Oncology; Pathology; Cancer; Disease; Receptor; Stromal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001746755,0.001656088,0.002722602,0.0003525201,0.0003566376,0.0008953229,0.0009318313,0.001397345,0.004150865],"category_scores_gemma":[0.001370472,0.0005725695,0.0008824063,0.0003666593,0.001344956,0.00105234,0.0003298057,0.00273072,0.0007276714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006069616,"about_ca_system_score_gemma":0.00128816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002471136,"about_ca_topic_score_gemma":0.0006725963,"domain_scores_codex":[0.9992149,0.0004371442,0.00004801496,0.0001115359,0.00007948638,0.0001090077],"domain_scores_gemma":[0.9980368,0.0005835389,0.0005300465,0.000139383,0.00009085545,0.0006193904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8272311,0.08128744,0.007246001,0.0008189142,0.0009545526,0.0003198449,0.0001668288,0.001578373,0.04040821,0.0001901047,0.001481245,0.03831742],"study_design_scores_gemma":[0.4798854,0.5067692,0.007178897,0.00002925808,0.0002240737,0.0002750198,0.00003497121,0.000909859,0.003392458,0.0001065711,0.001173354,0.00002091988],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994037,0.001817886,0.0006953185,0.0001630457,0.00007534152,0.001939376,0.0005438726,0.0000462719,0.0006818971],"genre_scores_gemma":[0.9874998,0.001687339,0.002344428,0.000706031,0.0003527143,0.004274463,0.001917771,0.00002094511,0.001196494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004150865,"threshold_uncertainty_score":0.01388603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5138175632808544,"score_gpt":0.5818905854513831,"score_spread":0.06807302217052869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}