{"id":"W2134348005","doi":"10.4049/jimmunol.1200873","title":"Ly49Q Positively Regulates Type I IFN Production by Plasmacytoid Dendritic Cells in an Immunoreceptor Tyrosine–Based Inhibitory Motif–Dependent Manner","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Protein tyrosine phosphatase; Immunoreceptor tyrosine-based activation motif; Biology; Cell biology; TLR9; Plasmacytoid dendritic cell; Interferon regulatory factors; Interferon; Receptor; Signal transduction; Immune system; Dendritic cell; Innate immune system; Gene expression; Gene; Immunology; SH2 domain; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134971,0.0002714544,0.0002602651,0.0001617386,0.000101375,0.0003209166,0.0001760369,0.000260863,0.001400979],"category_scores_gemma":[0.0001473685,0.0001026992,0.0002499929,0.00008945633,0.0002321147,0.0001882386,0.0002070608,0.0005747533,0.0007321105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638074,"about_ca_system_score_gemma":0.0001501811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002017205,"about_ca_topic_score_gemma":0.0002282234,"domain_scores_codex":[0.999781,0.0000556534,0.0000225197,0.00003492825,0.00004678189,0.00005907393],"domain_scores_gemma":[0.9998649,0.0000284156,0.00003626761,0.00001659672,0.00001714223,0.00003668607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001195794,0.0000230047,0.00009288136,0.0000119941,0.000001450225,0.00002841065,0.000003894032,0.00002233885,0.99926,0.00003546837,0.00002646167,0.0003744651],"study_design_scores_gemma":[0.00007821825,0.0004026388,0.006412566,0.000004681848,0.00001384221,0.0001552785,0.00002165614,0.001351251,0.9897045,0.00005067996,0.001800155,0.000004482489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995187,0.0009660636,0.001896123,0.0001177627,0.00004166899,0.00003407923,0.0003301273,0.00008755522,0.001339766],"genre_scores_gemma":[0.9970096,0.000444094,0.0007849202,0.00006620304,0.0000206265,0.00004694911,0.0003615048,0.00002283014,0.001243091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400979,"threshold_uncertainty_score":0.004686713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00740767652216028,"score_gpt":0.215216808082686,"score_spread":0.2078091315605257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}