{"id":"W2134367629","doi":"10.1128/mcb.00919-08","title":"Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the β-Globin Locus","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Biology; Chromatin; Locus control region; Histone; Histone-modifying enzymes; Transcription coregulator; Histone code; Histone H3; Cell biology; Transcription factor; Transcription (linguistics); Pioneer factor; Chromatin remodeling; Epigenetics; Acetylation; Molecular biology; Genetics; Promoter; Gene; Gene expression; Nucleosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179114,0.0001477741,0.0001133707,0.00007416714,0.000103498,0.0002037354,0.0001211628,0.000105894,0.0007012846],"category_scores_gemma":[0.0001632171,0.00009720398,0.00009489507,0.00005283989,0.0001726366,0.0001601103,0.0001737561,0.0001913355,0.0003151213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663229,"about_ca_system_score_gemma":0.0001126745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004043625,"about_ca_topic_score_gemma":0.0006485831,"domain_scores_codex":[0.9999311,0.000009695521,0.000007357473,0.00001711506,0.00001590777,0.00001881034],"domain_scores_gemma":[0.9998755,0.00002229717,0.00003634823,0.00002397948,0.00001375579,0.00002805181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004546086,0.000004648412,0.0008803631,0.000005783134,0.000001646837,0.00003424624,0.000006528012,0.00002655562,0.9979681,0.00005598926,0.000006535512,0.000964075],"study_design_scores_gemma":[0.00001210177,0.00009616948,0.03100271,0.000004022384,0.000009701757,0.0004541544,0.00002207068,0.0007378786,0.9658246,0.0001342245,0.00169824,0.000004138433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965496,0.0003161614,0.002384239,0.00002319672,0.000004062183,0.000003348836,0.00007953418,0.0000362258,0.0006036057],"genre_scores_gemma":[0.9982362,0.00009125877,0.0008660629,0.00001287638,0.000002364726,0.000002692758,0.0001661359,0.00001241309,0.0006100102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007012846,"threshold_uncertainty_score":0.002346039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394971724788533,"score_gpt":0.2445264723474855,"score_spread":0.2305767550996002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}