{"id":"W2134401708","doi":"10.1021/ol0258132","title":"Enantioselective Alkylation of Aldehydes with Chiral Organomagnesium Amides (COMAs)","year":2002,"lang":"en","type":"article","venue":"Organic Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Alkylation; Enantioselective synthesis; Reagent; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005052281,0.0001982203,0.0002119622,0.00005538942,0.00009153468,0.00002902078,0.0002021499,0.00008416577,0.00945783],"category_scores_gemma":[0.00006153053,0.0001782712,0.00005886795,0.0003982907,0.0001141005,0.0001936092,0.00003592309,0.0001577455,0.00005125173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000929165,"about_ca_system_score_gemma":0.0000191722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000708482,"about_ca_topic_score_gemma":0.000007186674,"domain_scores_codex":[0.9989704,0.00001285922,0.0002513755,0.0002889697,0.0002391738,0.0002372265],"domain_scores_gemma":[0.9993129,0.00006571865,0.0001874897,0.0002906527,0.00008062808,0.00006264308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001486489,0.00009241861,0.006601486,0.00009746449,0.00006160707,0.00000852178,0.0003440681,0.000007856704,0.9915568,0.00007884875,0.0004806591,0.0006554076],"study_design_scores_gemma":[0.0006485188,0.00002544698,0.001442374,0.00002421509,0.00005753855,0.00003373652,0.00008955197,0.0001256702,0.9967245,0.00003598305,0.0005564649,0.0002360345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992423,0.00007383138,0.0004723562,0.001794591,0.00003349368,0.00004966477,0.000009345021,0.0001118843,0.005031834],"genre_scores_gemma":[0.9976142,0.00001303699,0.0003705832,0.0002515762,0.0001411411,0.000005257425,0.00002495154,0.00004117056,0.001538091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009406578,"threshold_uncertainty_score":0.9914477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00841465371159294,"score_gpt":0.1814384918337548,"score_spread":0.1730238381221619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}