{"id":"W2134408498","doi":"10.2337/db11-0478","title":"miR-146a–Mediated Extracellular Matrix Protein Production in Chronic Diabetes Complications","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Fibronectin; Antagomir; Transfection; Downregulation and upregulation; Extracellular matrix; microRNA; Luciferase; Messenger RNA; Retinal; Untranslated region; Endocrinology; Molecular biology; Biology; Chemistry; Internal medicine; Cell biology; Medicine; Cell culture; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002286557,0.0002772755,0.0002412475,0.0002142153,0.0001457262,0.0003938815,0.0001148532,0.0002348497,0.0009338314],"category_scores_gemma":[0.0001608928,0.0001236549,0.0002630928,0.000194841,0.0001899515,0.0001414596,0.0001968067,0.0004661388,0.000231448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818988,"about_ca_system_score_gemma":0.0001271262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002325023,"about_ca_topic_score_gemma":0.0002515849,"domain_scores_codex":[0.9998753,0.00002889538,0.00001498655,0.00002948067,0.00003149002,0.00001983357],"domain_scores_gemma":[0.9998566,0.00001172894,0.00007572163,0.000008369739,0.00001911891,0.00002849715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002026133,0.0001973485,0.01514946,0.0005527443,0.0000981562,0.0007076837,0.00007429151,0.0001513423,0.9622036,0.0003547506,0.0004076089,0.01807697],"study_design_scores_gemma":[0.0003603601,0.002388418,0.5090076,0.0001809677,0.000370141,0.006894415,0.0002077423,0.003668697,0.4559366,0.0006751497,0.02027718,0.00003280131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668379,0.0255651,0.00334073,0.0002206627,0.00008869952,0.0000511314,0.0004196505,0.00007244651,0.003403673],"genre_scores_gemma":[0.9894696,0.005865902,0.002154948,0.0001320008,0.00005302566,0.0000625508,0.0003687368,0.00001121893,0.001881831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009338314,"threshold_uncertainty_score":0.003123939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328776747887207,"score_gpt":0.2326354663201792,"score_spread":0.2193476988413071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}