{"id":"W2134410269","doi":"10.1210/jc.2014-1266","title":"Cyclosporine A and Tacrolimus Reduce the Amount of GLUT4 at the Cell Surface in Human Adipocytes: Increased Endocytosis as a Potential Mechanism for the Diabetogenic Effects of Immunosuppressive Agents","year":2014,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; Sahlgrenska Universitetssjukhuset; Hjärt-Lungfonden","keywords":"GLUT4; Tacrolimus; Glucose transporter; Insulin; Endocytosis; Glucose uptake; Endocrinology; Insulin receptor; Internal medicine; Calcineurin; Insulin resistance; Pharmacology; Biology; Chemistry; Transplantation; Medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682783,0.0001897171,0.0002006274,0.0001445447,0.0001470123,0.0002811015,0.0001280872,0.0002508879,0.001057352],"category_scores_gemma":[0.0001279794,0.00007203817,0.0003246011,0.0001215425,0.0001621106,0.0001927388,0.0001108908,0.0003450262,0.0002079184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002106425,"about_ca_system_score_gemma":0.0001578176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004684643,"about_ca_topic_score_gemma":0.0005710557,"domain_scores_codex":[0.9998572,0.00003375684,0.00001899637,0.0000276125,0.00004171627,0.00002076649],"domain_scores_gemma":[0.9999044,0.00002772849,0.00002371479,0.00001517197,0.00001430673,0.00001470609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000305126,0.00004376153,0.0004933234,0.00005840585,0.00001475459,0.00005887011,0.000009870727,0.00004876995,0.9956399,0.00006645438,0.00003438379,0.003226409],"study_design_scores_gemma":[0.00003160557,0.0003830722,0.01315328,0.000005146316,0.00004094244,0.0004251931,0.00002555504,0.0005084666,0.983734,0.00003440706,0.001654241,0.00000406445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911266,0.00451537,0.002684089,0.0001496459,0.00004289632,0.00002087838,0.000137438,0.00004058995,0.001282425],"genre_scores_gemma":[0.9956929,0.001603183,0.001495957,0.00008545591,0.00002252845,0.00002142386,0.0001030602,0.00001266927,0.0009627608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057352,"threshold_uncertainty_score":0.003537238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295074245853587,"score_gpt":0.3129332391434511,"score_spread":0.2999824966849152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}